The ability to degrade type IV collagen, the major component of the basement membrane, is unique to gelatinases A and B. These two matrix metalloproteinases (MMPs) are most often linked to the malignant phenotype of tumor cells, and their expression is elevated in several cases of human tumor aggressiveness and overall survival. By gelatin zymography, we verified MMP activity in the urine of pa...

abstract introduction: bladder cancer is the most common tumor of the urinary tract and the ninth cancer in terms of incidence in both sexes in the world. bladder cancer is the second most common cancer in men in iran. this study aimed to investigate the trend of death from bladder cancer in iran.materials and methods: this study was conducted by the use of data on mortality in iran during 2006...

BACKGROUND Of all cancer tumours, urinary bladder cancer is the fourth must common in men and the seventh in women. The aim of this work was to answer the question whether tissue polypeptide antigen (TPA-M) determination in patients after electroresection of urinary bladder cancer can be used to establish the probability of tumour recurrence. MATERIAL AND METHODS The research included 98 pati...

botulinum toxin (bt) is a potent presynaptic neuromuscular blocking agent which induces selective, reversible muscle weakness for months when injected intramuscularly.during recent years bt has revolutionized the treatment of previously intractable symptoms of detrusor overactivity. based on a systematic search of the pubmed database,a review of the current literature on the use of onabotulinum...

BACKGROUND Urinary bladder cancer is the third leading cancer in male in Turkey. The incidence rates of bladder cancer are 13.0 and 2.1/100,000 for males and females, respectively, in Turkey. Smoking and occupation are the main causes of urinary bladder cancer. Our goal was to investigate the etiologic factors of urinary bladder cancer in our region to improve our preventive services. METHODS...

Previous work in our laboratory has demonstrated that antisera to proteins found in the urine of bladder cancer patients can distinguish between urine samples from these patients and those from normal individuals when tested by a complementfixation assay. Antisera which were reactive with individual tumor-associated antigens were used to detect the antigens in the urine of bladder cancer patien...

Previous work in our laboratory has demonstrated that antisera to proteins found in the urine of bladder cancer patients can distinguish between urine samples from these patients and those from normal individuals when tested by a complement-fixation assay. Antisera which were reactive with individual tumor-associated antigens were used to detect the antigens in the urine of bladder cancer patie...

About 180,000 new cases of urinary bladder cancer are diagnosed each year in the European Union. The most relevant risk factors are occupational exposure to aromatic amines and cigarette smoking (Golka et al. Recently, genome-wide association studies have successfully identified several urinary bladder cancer susceptibility loci (review: it has been shown that several high risk alleles of singl...