higher in diabetic than in non-diabetic stone formers, but the difference was strikingly more marked in women than in men with a ratio of 3.8 vs 1.7 (P1⁄4 0.003). It was shown recently that the metabolic syndrome presently affects >40% of the population aged 60 years in the US [4], which is in keeping with the observation that uric acid nephrolithiasis was highly prevalent in our diabetic stone...

A high urinary pH is main risk factor for the calcium phosphate stone formation; however, its pathophysiologic mechanism has not been fully understood. The introduction of Topiramate in the treatment of various neurological disorders has been complicated by metabolic acidosis, significant hypocitraturia, elevated urinary pH, and calcium phosphate stone formation. This model provides a probe to ...

Uric acid stones are the most readily dissolvable of all types of urinary stones. By maintaining urinary pH between 6.2-6.8 with the use of sodium acid citrate or uralyt-U and reducing serum uric acid by allopurinol, we tried to dissolve 107 stones in 67 patients. Ninety three (86.9%) stones were dissolved and 6 (5.6%) passed spontaneously within a period of one year. Eight (7.5%) stones were r...

To get complete information about the chemical composition and physicochemical principles underlying the formation of stone there is a need for more precise information. At present there is no single analytical procedure that provides an exact quantitative analysis of urinary calculi. In this present procedure it is assumed that only calcium oxalate monohydrate, hydroxyapatite, or magnesium amm...

BACKGROUND The aim of the study was to measure the content of methylated purines that appear as admixtures in uric acid stones. METHODS We analyzed urinary calculi from 48 residents of Western Pomerania who underwent surgery at the urology ward in Szczecin. Stone samples were dissolved in 0.1 mol/L NaOH. Extracts were diluted in 50 mmol/L KH(2)PO(4) and analyzed by reversed-phase HPLC with ul...

PURPOSE To assess the potential of dual-energy computed tomography (DECT) to identify urinary stone components, particularly uric acid and calcium oxalate monohydrate, which are unsuitable for extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS This clinical study included 246 patients who underwent removal of urinary stones and an analysis of stone components between November...

PURPOSE We compared the effect of 3 animal protein sources on urinary stone risk. MATERIALS AND METHODS A total of 15 healthy subjects completed a 3-phase randomized, crossover metabolic study. During each 1-week phase subjects consumed a standard metabolic diet containing beef, chicken or fish. Serum chemistry and 24-hour urine samples collected at the end of each phase were compared using m...

OBJECTIVES To give a comprehensive and focused overview on the current knowledge of the causal relations of metabolic syndrome and/or central obesity with kidney stone formation. METHODS Previous reports were reviewed using PubMed, with a strict focus on the keywords (single or combinations thereof): urolithiasis, nephrolithiasis, kidney stones, obesity, metabolic syndrome, bariatric surgery,...

Kidney stone formers may feel doomed to a life of unpredictable flank pain, periodic surgical intervention, and concomitant loss of work and daily pleasures. Indeed, if untreated, those who have formed one calcium oxalate stone have a 50% chance of forming additional stones within 10 years (Menon & Resnick, 2002). With appropriate education, patients can exercise some control over stone disease...

OBJECTIVE To report preliminary information on urinary stone composition in patients who are either overweight or obese with kidney stone disease. METHODS A cohort of patients (n = 138) with nephrolithiasis were prospectively followed from January 2011 for 18 months. Of those, 64 (46%) were found to be overweight with body mass index ≥ 25 kg/m(2) and 74 (54%) were obese with body mass index ≥...