Congenital diffuse Melanosis is one of the rarest clinical manifestations of hereditary universal Melanosis and only few cases have been reported all over the world. The presented case is a 54-year-old man who presented to us complaining of erythematous annular lesions on his face and neck since 8 months ago. Diffuse pigmentation of his skin took our attention. According to the patient, d...

PURPOSE To describe the clinical and histopathological features of a 61-year-old male with a history of eczema, asthma and schizophrenia on long-term chlorpromazine medication, who developed a unilateral limbal tumour in association with bilateral melanosis. PROCEDURES The patient was referred for a routine cataract assessment, and an incidental pink gelatinous limbal lesion was detected on t...

Figure 3 Atypical acquired melanosis, shown by clusters ofabnormal melanocytes in the epithelium, migrating awayfrom the basement membrane. Squamous metaplasia ofthe epithelium, with loss ofgoblet cells, is also seen. Haematoxylin and eosin. Magnifcation x300. We present an unusual case in which conjunctival melanoma was preceded by excision of a lentigo maligna melanoma ofthe ipsilateral lower...

PURPOSE To evaluate clinical features and risks for transformation of conjunctival primary acquired melanosis (PAM) into melanoma. METHODS Retrospective chart review and Kaplan-Meier estimates of times to PAM enlargement, recurrence, and transformation into melanoma. MAIN OUTCOME MEASURES PAM enlargement, recurrence, and transformation into melanoma. RESULTS The mean patient age at diagno...

AIM To evaluate topical mitomycin C (MMC) chemotherapy in the treatment of conjunctival melanoma and primary acquired melanosis with atypia. METHODS In a phase I clinical trial, 10 patients with conjunctival melanoma and/or primary acquired melanosis with atypia were treated with topical MMC 0.04% four times daily. Four patients were given MMC for 28 days as a primary treatment. Six patients ...