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This article presents a mathematical model of glucose homeostasis that is valid during physical activity. Known changes in glucose dynamics during exercise were accounted for in the model, and exercise itself was detected and quantified through heart rate (beats per minute). The model was successfully fit to 21 type 1 diabetic subjects during a hyperinsulemic clamp protocol, and performance of ...
J. A. Prevedello ([email protected]), Programa de Pós-Graduação em Ecologia, Univ. Federal do Rio de Janeiro, Brazil. JAP also at: Lab de Vertebrados, Depto de Ecologia, Univ. Federal do Rio de Janeiro, CP 68020, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-590, Brazil. – M. S. L. Figueiredo, C. E. V. Grelle and M. V. Vieira, Lab de Vertebrados, Depto de Ecologia, Univ. Federal do Rio...
[1] Mangrove forests are highly productive but globally threatened coastal ecosystems, whose role in the carbon budget of the coastal zone has long been debated. Here we provide a comprehensive synthesis of the available data on carbon fluxes in mangrove ecosystems. A reassessment of global mangrove primary production from the literature results in a conservative estimate of 218 ± 72 Tg C a . W...
Objective: Assess whether reform in the Tanzanian medicines delivery system from a central 'push' kit system to a decentralized 'pull' Integrated Logistics System (ILS) has improved medicines accountability. Methods: Rufiji District in Tanzania was used as a case study. Data on medicines ordered and patients seen were compiled from routine information at six public health facilities in 1999 und...
A physiologically based pharmacokinetic (PBPK) model was developed that describes the concentration and biodistribution of fluorescently labeled nanoparticles in mice used for the controlled delivery of dexamethasone in acute lymphoblastic leukemia (ALL) therapy. The simulated data showed initial spikes in nanoparticle concentration in the liver, spleen, and kidneys, whereas concentration in pl...
It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review, we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the reticuloendothelial system. Studies on these cells resulted in a substantial literature spanning immunology, hematology, biochemistry, and pathology. Early histolo...
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