high-performance liquid chromatography (hplc) methods employing ultraviolet (uv) detector are not sufficiently sensitive to measure the low plasma concentrations following single oral dose of imipramine. therefore, in the present study a simple, rapid and yet sensitive hplc method with uv detection was developed and validated for quantitation of imipramine in human plasma samples. an efficient ...

tetracyclines (tcs) are broad-spectrum antibiotics that are used widely in veterinary medicine. the present study was carried out to trace the residues of oxytetracycline (otc) and tetracycline (tc) in pasteurized milk that is marketed in tehran with the use of a high performance liquid chromatography (hplc). ninety milk samples were collected during five sequential days from the products of si...

tetracyclines (tcs) are broad-spectrum antibiotics that are used widely in veterinary medicine. the present study was carried out to trace the residues of oxytetracycline (otc) and tetracycline (tc) in pasteurized milk that is marketed in tehran with the use of a high performance liquid chromatography (hplc). ninety milk samples were collected during five sequential days from the products of si...

Purpose: To develop, validate and compare two chromatographic methods - high performance liquid chromatography with diode array detector ((HPLC-DAD) ultraviolet detection (UPLC-UV) for the effective analysis of polyphenols in Moringa oleifera leaves.Methods: HPLC-DAD UPLC-UV were applied accurate determination eleven major leaves. The conditions was determined on C18 column by gradient elution ...

In a previous communication [l] we reported a procedure for the serum determination of midazolam using gas chromatography (GC) with a nitrogenselective detector. GC with nitrogen-selective detection resulted in a selective procedure for the direct determination of midaxolam with a sensitivity of 50 ng/ml. We present, in this paper, a procedure for the direct determination of midazolam and its m...

Tetracyclines (TCs) are broad-spectrum antibiotics that are used widely in veterinary medicine. The present study was carried out to trace the residues of oxytetracycline (OTC) and tetracycline (TC) in pasteurized milk that is marketed in Tehran with the use of a High Performance Liquid Chromatography (HPLC). Ninety milk samples were collected during five sequential days from the products of si...

A combination of high performance size exclusion chromatography with organic carbon detector and ultraviolet detector coupled with peak-fitting technique and fluorescence excitation-emission matrix spectrometry applied fluorescence regional integration method was conducted to determine the characteristics of organic matter during nitrification. The batch scale of bionet nitrification without or...

a special type of silica-based columns has been recently introduced into the market which is called narrow-bore columns. they have lower internal volume than the standard high-performance liquid chromatography (hplc) columns and thus reduce the solvent consumption by almost 80%.    a simple, accurate and environmentally friendly reversed phase- hplc (rp-hplc method) which could be used in fast ...

A newly developed single quad mass spectrometry (MS) detector was coupled to a ultra-high performance liquid chromatography (UPLC) system and implemented in the routine quality control (QC) and impurity analysis of four therapeutic peptides, namely bleomycin sulfate, tyrothricin, vancomycin HCl and bacitracin, which were selected given their multi-component drug nature and their closely structu...

Lapatinib is a small molecule, heterocyclic quinazoline derivative. The drug used for targeted therapy of patients with breast cancer, in which there overexpression the human epidermal growth factor receptors (HER/ErbB). This review devoted to studying modern instrumental methods qualitative and quantitative analysis lapatinib, can be both quality control standardization (of bulk pharmaceutical...