Background: Chronic graft versus host disease (ch.GVHD) is the most frequent late complication after allogenic stem-cell transplantation. Systemic immunosuppressive agents are usually required to control the disease. Psoralen plus UVA (PUVA) has been used for the treatment of ch.GVHD with variable beneficial effects. The objective of this study was to assess the efficacy and safety of a r...

background: different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats. objective: in this study we worked out the effect of methoxsalen together with ultraviolent a (uva) radiation on mature balb/c mice spermatogenesis. materials and methods: the ld50 standard was determined 160 mg/kg and the uva dose which causes erythema was calculated 0.046 j...

Abstract Albinism, derived from the Latin word albus meaning white, is a rare genetic condition characterized by an absence of melanin leading to individual having pale skin, eyes and hair. It believed that Tanzania has highest rate albinism in Africa with autosomal recessive gene being carried one 19 Tanzanians impacting 1400 people (Cruz-Inigo AE, Ladizinski B, Sethi A. Albinism Africa: stigm...

Cutaneus malignant melanoma (MM) is a highly malignant tumour of the skin and is responsible for more deaths than any other skin cancer (Imko-Walczuk et al., 2009). Melanocytes originate from the neural crest and in contrast to Langerhans' cells are located amongst the basal layer of the epidermis, hair bulb, eyes, ears, and meninges (Bandarchi et al., 2010; Fitzpatrick, 1971; Nordlund & Boissy...

No. 377.24 URL, XP008095016 & FASEB Meeting on Experimental Biology: Translating the Genome, San Diego, CA USA, Apr. 11-15, 2003 ISSN: 0892-6638 *Abstract*. Cook, et al. "Neuronal Damage induced by polychlorinated biphenyls is partically reversed by cerium oxide nanoparticles" [online] vol. 2003, 2003, XP008095032 Retrieved from the internet: URL http://sfn.scholarone.com/itin2003/main.htm ]?ne...

T umor suppressor p53 (TP53) was discovered more than two decades ago to be frequently mutated in diverse types of human cancer (1, 2), and the mutation frequency was shown to be even higher by whole-exome sequencing of the cancer genome (3, 4). In PNAS (5), Chen et al. show a dose dependency between exposure to aristolochic acid (AA), a known human carcinogen and nephrotoxin, and the TP53 muta...