This study investigated whether ulcer prevention would be greater with the combined use of an acid-inhibiting agent, ranitidine, given together with a mucosal-protective agent, sucralphate. Duodenal ulcers were induced in rats with the secretagogues pentagastrin and bethanechol. Subtherapeutic doses of ranitidine (5 mg/kg/6 hours) and sucralphate (50 mg/6 hour) yielded an ulcer index of 4.0 and...

The effect of Methanolic, chloroform and diethel ether extracts of Mimosa pudica was investigated in rats to evaluate the anti-ulcer activity by using three models, i.e. Aspirin, Alcohol and pyloric ligation models experimentally induced gastric ulcer. The parameters taken to assess anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The result...

To investigate the gastroprotective activity of ethanolic leaf extract of Ficus religiosa (F. religiosa) in different experimental models of gastric ulcer in rats.The ethanolic leaf extract of F. religiosa were studied at two dose levels (250 and 500 mg/kg, oral) in rats against absolute cold stress induced ulcer and pyloric ligation induced gastric ulcer. Ranitidine (50 mg/kg, oral) was used a...

the aim of the study was to study the anti-ulcer activity of the methanolic extract of the leaves of capparis zeylanica linn on experimental animal models. the methanol extract of capparis zeylanica linn. leaves was investigated for anti-ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats. hcl-ethanol induced ulcer in mice and indomethacin induced ulcer in rats at...

gastric ulcer is one of the most prevalent gastrointestinal (gi) disorders, which affects approximately 5-10% of people during their life. in recent years, plentiful works have been carried out on herbal medicine to clarify their potential efficacy in gastric ulcer prevention or management. tripleuro-spermum disciforme is one of the indigenous plants that is readily available and has been tradi...

Osyris quadripartita (OQ) Salzm. ex Decne. has been used to treat peptic ulcer disease in Ethiopian folk medicine, but its efficacy has not been validated. The present study was therefore carried out to evaluate the anti-ulcer activity of 80% methanol leaf extract of OQ in rats. The effect of OQ extract on gastric ulcer in rats in pylorus ligation-induced and ethanol-induced models was studied ...

conclusions tg showed protective effect against ethanol induced gastric ulcer. this study confirmed traditional medicine claims of tg. objectives the aim of the present study was to determine the acute toxicity and protective effect of hydroalcoholic extract of tg (hetg) against ethanol induced gastric ulcer. materials and methods male wistar rats were divided into five groups (n = 7). hetg at ...

Daemia extensa is a well-known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antioxidant, in-vitro antibacterial and antifungal activity. The aim was to search for anti-ulcer activity of ethanolic extract of Daemia extensa seed. Ethanolic extract of Daemia extensa seed was considered for its potential to protect gastric mucosa agai...

The present study was undertaken to determine the anti-ulcer and antioxidant potential of GutGard, a standardized extract of Glycyrrhiza glabra commonly known as licorice. Effect of various doses (12.5, 25, and 50 mg/kg, po) of GutGard was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin induced gastric mucosal injury in rats. Anti-ulcer activity was evalu...

The aim of this study is to evaluate the anti-ulcer activity of chloroform extract of leaves of Cayratia pedata (Lam). The chloroform extract of Cayratia pedata (CECP) was investigated for its anti-ulcer activity against pylorus ligation and ethanol induced gastric ulcers in rats. Ranitidine (50mg/kg,p.o.) and misoprostol (100ug/kg,p.o.) were used as standard drugs. A significant (p<0.01) anti-...