Free radicals especially reactive oxygen metabolites can damage DNA, protein, enzymes, and membrane lipids. Lipid peroxidation in hepatocyte membrane may be involved in hepatic diseases. Antioxidants may inhibit this reaction. Due to oxidant-antioxidant imbalance, free radicals may cause destructive effects. For several years, scientists tried to find antioxidant compounds. In this study, the e...

Although coenzyme Q10 (CoQ10) serves as an antioxidant and energy source for spermatozoa when added to stallion semen before cooling or freezing, the effects of feeding CoQ10 on quality have not been studied. We assessed daily oral ingestion CoQ10-ubiquinol by stallions their plasma concentrations quality. Seven mature Andalusian ate 1g ubiquinol/day 4 weeks followed a 4-week washout period. Fo...

AIM To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration. METHODS Patients with type 2 diabetes and PDRP were determined to be the case group (n=50). The control group was consist of healthy individuals (n=50). Plasma CoQ10 and malondialdehyde (MDA) levels were measured in both groups. RESULTS Ubiquinone-10 (Coenzyme Q1...

OBJECTIVE To evaluate the effectiveness of coenzyme Q(10) treatment in improving semen quality in men with idiopathic infertility. DESIGN Placebo-controlled, double-blind randomized trial. SETTING Andrology Unit, Department of Internal Medicine, Polytechnic University of Marche, Italy. PATIENT(S) Sixty infertile patients (27-39 years of age) with the following baseline sperm selection cri...

The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated. Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2(')-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SO...

Abstract Candidemia caused by Candida spp. is a serious threat in hospital settings being major cause of acquired infection and death possible contributor to Covid-19 mortality. incidence has been rising worldwide following increases fungicide-resistant pathogens highlighting the need for more effective antifungal agents with novel modes action. The membrane-bound enzyme alternative oxidase (AO...