Background: Diabetes mellitus is an endocrine disorder of carbohydrate metabolism resulting primarily from inadequate insulin release (type I) or insulin insensitivity coupled with inadequate compensatory insulin release (type II). Oxidative stress is one of the complications of diabetes that increases in both types of diabetes and treatment with antioxidants can reduce the complications of dia...

conclusions our study showed a significant association between h63d and c282y mutations and the risk of type 2 diabetes in iranian population. background type 2 diabetes (t2d) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. objectives regarding the relationship between type 2...

    Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract (BVFE) which have important role in regulation of serum glucos...

Background: Pancreatic islet transplantation is one of the most promising strategies for treating patients with type I diabetes mellitus.Objective: We aimed to assess the immunoisolation properties of the multilayer encapsulated islets using alginate-chitosan-PEG for immunoprotection and insulin secretion from the encapsulated islets induced under differe...

    Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract (BVFE) which have important role in regulation of serum glucos...

background and aim: the aim of this study was to determine the effect of legume intake in therapeutic lifestyle change (tlc) on fasting insulin, fasting blood glucose, hba1c and homeostasis model assessment insulin resistance (homa-ir) in patients with type 2 diabetes. materials and methods: in this randomized crossover trial, 31 subjects with type 2 diabetes in the age range of 50 to 80 years ...

Introduction: Antioxidant agents have beneficial effects in diabetes mellitus. Daucus carota seeds extract has been shown to possess antioxidant activity. In this study, the effect of the methanolic extract of Daucus carota seeds on carbohydrate metabolism and morphology of pancreas was investigated in type I diabetic male rats. Methods: Type I diabetes mellitus was induced in male Wistar ...

introduction: type i diabetes mellitus is caused by autoimmune destruction of the insulin-producing β-cells. a new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells. methods: human embryonic stem cell lines (royan h1) were used to produce embryoid bodies. differentiation carried out by growth factor-mediated sel...

background type 1 diabetes mellitus is one of the metabolic diseases that cause insulin-producing pancreatic ß cells be destroyed by immune system self-reactive t cells. recent­ly, new treatment methods have been developed including use of the stem cells, ß islet cells transplantation and gene therapy by viral and non-viral gene constructs. objectives the aim of this project was preparing the n...