Brief Summary: This Mendelian randomization study analysed genetic data from 454,023 individuals the UK Biobank and 15,573 type 1 diabetes (T1D) cases other cohorts provides strong evidence that larger childhood body size increases T1D risk, independently at birth during adulthood.

Brief Summary: This in vitro study explored the reactivity to preproinsulin of CD8 T cells obtained from pancreatic islets individuals with and without type 1 diabetes (T1D). The main finding was that T1D donors were highly reactive peptides throughout entire protein.

The prevalence of celiac disease autoimmunity or tissue transglutaminase autoantibodies (TGA) amongst patients with type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) in the Chinese population remains unknown. This study examined the rate of celiac disease autoimmunity amongst patients with T1D and AITD in the Chinese population. The study included 178 patients with type 1 diabetes and...

Diabetes mellitus type 1 (T1D) develops as a result of the interaction genetic and environmental factors. Genetic predisposition to T1D turns into clinical reality only in half hereditary cases, which indirectly indicates importance external factors, significance is periodically reviewed. Retrospective prospective foreign national studies were included. PubMed, Medline eLibrary searched. Modern...

OBJECTIVE To evaluate the frequency of depressive symptoms and the diagnosis and management of depression in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in the Pediatric Diabetes Consortium T1D and T2D registries. RESEARCH DESIGN AND METHODS The Children's Depression Inventory (CDI) 2 Self-Report (Short) version was completed by 261 T1D and 339 T2D youth aged 10-17 yea...

Brief Summary: Despite provision of free insulin by the Changing Diabetes in Children (CDiC) program, mortality remains high children and adolescents with type 1 diabetes (T1D) Cameroon, particular rural settings families no formal education.

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease caused by the immune-mediated reduction of β cells, resulting in lifelong dependence on exogenous insulin administration. We studied impact M1/M2 macrophages cell level. obtained healthy state (absence T1D) and unhealthy (presence T1D). found that state, levels are decreased with continuous alternative switch between M1 M2 macrophag...

The territorial differences in the prevalence of type 1 diabetes mellitus (T1D) around the world were previously reported (Amos et al., 1997; Green & Patterson, 2001; Lévy-Marchal, 2001), but the data were based on the study of juvenile T1D epidemiology, i.e., in patients diagnosed with T1D before the age of 15 years. These data became the basis for the epidemiological evaluation of the whole T...