background: the wilm’s tumor gene 1 (wt1) encodes a zinc finger transcription factor that is inactivated in a subset of wilm’s tumors. it plays a crucial role in growth, proliferation and development of some embryonic and adult organs. wt1 is expressed as a tumor associated antigen (taa) in various types of solid and hematopoietic malignancies and can be employed as a useful marker for targeted...

BACKGROUND Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of a 'tumorassociated' acute respiratory distress syndrome (ARDS) has been hypothesized. CASE REPORT We report the clinical course of a 19-year-...

Lung cancer is the most common factor of cancer-related deaths and about 85% of lung cancer is non-small cell lung cancer (NSCLC). MUC1, known as the attached protein or trans-membrane protein, is a kind of protein with highly glycosylation (greater than 50%) and high molecular weight (Mr>200*103). MUC1 is overexpressed in many malignancies, and as a tumor-associated antigens (TAAs), it exposes...

Cytotoxic T lymphocytes (CTL) kill target cells on the basis of cell-surface antigen recognition and are important in the host response to tumors, transplants, and viruses. CTL react with a wide variety of antigens including minor and major histocompatibility alloantigens and antigens expressed by syngeneic cells, such as from haptens, tumorassociated products, and viruses. CTL are generated by...

The use of novel materials for drug delivery and therapeutic applications present the potential for eradicating many harmful diseases such as cancer and heart disease. Nanoparticles including quantum dots (QDs) and gold nanoparticles provide a more viable and effective alternative to conventional techniques used for diagnostic and therapeutic applications. An improvement in the accuracy and tim...

Purpose The T-box family transcription factor Brachyury is overexpressed in a variety of human carcinomas, including lung, breast, colon, ovarian and prostate. Brachyury has been shown to promote epithelial to mesenchymal transition (EMT) in tumor cells, a critical step in the path to metastasis. An HLA-A2 epitope of Brachyury has been shown to expand human T cells that are capable of lysing Br...

Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes to the tumorigenic activities of cancer stem-like cells remains unclear. In this study, we found that a characteristic of cancer stem-like cells from chemoresistant tumors (CSC-R) is the ability to produce a variety of proinflammatory cytokines and t...

Purpose: To use gene transcript profiling to identify cancer-associated gene expression. Experimental Design: Methods included (i) marker discovery using laser capture microdissection (LCM)-assisted specimen preparation and antisense RNA-long serial analysis of gene expression (aRNALongSAGE) on matched colon cancer and uninvolved colon tissue specimens (n 1⁄4 5). Candidate tumorassociated genes...

In lung cancer, platelet-derived growth factor receptor a (PDGFRa) is expressed frequently by tumorassociated stromal cells and by cancer cells in a subset of tumors.We sought to determine the effect of targeting stromal PDGFRa in preclinical lung tumor xenograft models (human tumor, mouse stroma). Effects of antihuman (IMC-3G3) and anti-mouse (1E10) PDGFRa monoclonal antibodies (mAb) on prolif...

The tumormicroenvironment mediates induction of the immunosuppressive programmed cell death-1 (PD-1) pathway, and targeted interventions against this pathway can help restore antitumor immunity. To gain insight into these responses, we studied the interaction between PD-1 expressed on T cells and its ligands (PD-1:PD-L1, PD-1:PD-L2, and PD-L1:B7.1), expressed on other cells in the tumor microen...