nowadays brain tumors remain as a significant cause of morbidity and mortality and are often treatment refractory. the grading of brain tumor has an important implication in clinical management. currently, magnetic resonance spectroscopy (mrs) is an important modality in evaluating and grading brain tumors. the aim of this study is  evaluation of metabolites in the differentiation of brain tumo...

BACKGROUND AND OBJECTIVES The continuous progress in treatment options for pancreatic adenocarcinoma has lead to a re-evaluation of prognostic markers. In this study the prognostic relevance of DNA Index and classical histopathological parameters with regard to disease-free (DFS) and overall survival (OS) was analyzed within the CONKO-001 patient population. METHODS One hundred forty three fr...

Background and objective: Clear Cell Renal Cell Carcinoma (CCRCC) is the most common adult renal neoplasm. Staging and grading of RCC are important predictors of survival. Fuhrman nuclear grading is widely used for CCRCC, the subjective nature of which has prompted more objective methods to evaluate nuclear features. Furthermore, Ki-67, a reliable marker of cellular pr...

Histopathologic grading of astrocytic tumors based on current WHO criteria offers a valuable but simplified representation of oncologic reality and is often insufficient to predict clinical outcome. In this study, we report a new astrocytic tumor microarray gene expression data set (n = 65). We have used a simple artificial neural network algorithm to address grading of human astrocytic tumors,...

The treatment and prognosis for a tumor depend to a large extent on its stage. The goal of this article is to analyze to what extent tumor grading can be performed automatically using the OWLDL description logic language. We focused on the grading of lung tumors. Section 2 is a review of the authoritative cancer ontology, in which we conclude that the NCIT has to be extended in order to perform...

The prognostic value of histopathologic grading of oral squamous cell carcinomas (SCC) has varied from not any to highly significant. BRODERS' method of grading was compared with a modification of a recent malignancy grading system recommended by ANNEROTH et al. which was performed only within the histologically most invasive areas of the tumors. Cox's multivariate survival analyses showed that...

Purpose: While grading the tumor, histopathological evaluation of invasive front of the tumor is important as the morphological features registered reflect the important biological events within the tumor cells. This study was undertaken to determine the prognostic value of malignancy grading and Argyrophilic Nucleolar Organizer Region (AgNOR) method in assessment of proliferative activity at t...