Merkel cell carcinoma (MCC) is a rare and aggressive cancer of the skin with ∼30% mortality. Around 80% MCC tumors originate from integration polyomavirus (MCPyV) DNA into host genome, leading to expression viral T-antigen oncoprotein ultimately, tumorigenesis. Though PD-1 pathway blockade has significantly improved outcomes for advanced MCC, many patients do not benefit or develop resistance t...

conclusions the results revealed that the novel multi-epitope dna construct could be an effective candidate in tuberculosis vaccine development, and it is qualified to investigate its potential to induce cd4 and cd8 t- cell immune response in the experimental animal model. results mhc class i-and class ii-predicted epitopes showed a high potential to binding to human hlas alleles, with global b...

CAR-T cell immunotherapy involves genetically reprogrammed T-lymphocytes that interact with cancer cells and activate an anti-tumor immune response. This therapy has been approved for clinical use hematological cancers, but new challenges have emerged in the treatment of solid tumors. Some include heterogeneity antigen expression found tumors, including antigen-positive non-tumoral cells, inhib...

cystoscopy and urinary cytology are currently the basis for diagnosis and ‎follow-up of bladder tumors. research to find a sensitive and specific tumor ‎marker for diagnosis of bladder tumor is actively underway, however, due to low sensitivity ‎and high cost of cytology. this cross-sectional study was performed in 65 patients to evaluate whether urinary bladder ‎cancer (ubc) antigen level can ...

objective: for immunotherapy of human papillomavirus (hpv) -16-associated cervical cancers the e7 protein is considered a prime candidate. however it is a poor inducer of cytotoxic t-cell response, when being used as a singular antigen in protein vaccination. hence, in this study we focused on the utilization of a vaccine delivery system for prevention or treatment of cervical cancer. materials...

Abstract Glioblastoma (GBM) and brain metastases remain largely resistant to immunotherapeutic intervention. T cell exhaustion, a differentiation state characterized by loss of function persistence, contributes this resistance. Two exhaustion subsets, progenitor (Tex_prog) terminal (Tex_term), have been identified, where only Tex_prog responsive immunotherapy. To date, the dynamics characterist...