Sonodynamic therapy has been in the limelight for cancer treatment due to its deep tissue penetration and clinical safety. Nevertheless, a low level of oxygen tumor microenvironment diminishes therapeutic effect sonodynamic by inducing angiogenesis. In this article, we reported combinatorial strategy combining with anti-angiogenesis, which can successfully achieve inhibition angiogenesis suppre...

Abstract Background Tumor angiogenesis, immunosuppression, and progression are all closely correlated with the tumor microenvironment (TME). Immune evasion is supported by both M2 phenotype tumor-associated macrophages (TAMs) vascular aberrations in TME. TME reprogramming a promising therapeutic approach for treating tumors. Anti-angiogenesis has power to control polarization of macrophages, pr...

angiogenesis which is the recruitment of new blood vessels is a critical process in several chronic diseases and is an essential component of tumor or cancer progression. development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. in this study the effect of chlordiazepo...

The formation of new blood (angiogenesis) and lymphatic (lymphangiogenesis) vessels are major events associated with most epithelial malignancies, including breast cancer. Angiogenesis is essential for cancer cell survival. Lymphangiogenesis critical in maintaining tumoral interstitial fluid balance importing tumor-facilitatory immune cells. Both vascular routes also serve as conduits metastasi...

Angiogenesis is required in cancer, including gynecological cancers, for the growth of primary tumors and secondary metastases. Development anti-angiogenesis therapy cancers improvement its efficacy have been a major focus fundamental clinical research. However, survival benefits current anti-angiogenic agents, such as bevacizumab, patients with are modest. Therefore, better understanding angio...

the macrophages role within the tumor microenvironment has amended by a variety of factors, thus serves a vital role in tissue morphogenesis. the role of macrophages in health and disease differs enormously as the macrophage has shown dual functions. macrophage has a basic role in antigen presentation serving as the first line of defense in diseases. however the presence of cytokines and growth...

Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...