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An attempt was made to sustain the release of Betahistine hydrochloride by complexation technique using strong cation-exchange resin, Tulsion T344. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, swelling time, ratio of drug : resin, and temperature. The resinate was evaluated for micromeritic properties and characterized using XRPD and IR. For ...

OBJECTIVE Previous studies have shown that miR-335 plays an anti-tumor role in several types of cancer. However, whether it is able to regulate the tumorigenesis of osteosarcoma (OS) has not been fully investigated. The present study was designed to study its potential role in regulating apoptosis of OS cells. MATERIALS AND METHODS The expression of miR-335 in a total of 18 paired OS tumor ti...

Throughout their history, humans have devised a number of approaches and strategies to reducing (perceived) uncertainty or the psychological impacts of uncertainty, and to function and thrive in a partially unknown world. A certain world begets certain ‘best strategies’ for survival; an uncertain world necessitates a larger portfolio of options and approaches, and means for choosing among them....

AIM To identify the role of serum MicroRNA-335 (miR-335) in determining the treatment response to Trans-arterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC) and their prognosis after TACE. METHODS A total of 125 HCC patients were enrolled in this study. All these patients underwent TACE and the treatment response was evaluated. All patients were followed for progn...

MicroRNA (miR)-335 and Rho-associated serine-threonine protein kinase 1 (Rock1) is ectopically expressed in multiple malignant tumors including osteosarcoma. The present study aimed to clarify whether the combined ectopically expressed miR-335 and Rock1 was correlated with clinicopathological features and prognosis in patients with osteosarcoma. The expression of miR-335 and Rock1 in 91 osteosa...

http://bmj.com/cgi/content/full/335/7611/105 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/335/7611/105#otherarticles 2 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/335/7611/105#BIBL This article cites 11 articles, 3 of which can be accessed free at: Rapid responses http://bmj.com/cgi/ele...

http://bmj.com/cgi/content/full/335/7631/1206 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/335/7631/1206/DC1 "Extra figures (paraphimosis and minor hypospadias)" References http://bmj.com/cgi/content/full/335/7631/1206#BIBL This article cites 30 articles, 7 of which can be accessed free at: Rapid responses http://bmj.com/cgi/el...

INTRODUCTION MicroRNAs (miRNAs) are noncoding RNAs that regulate multiple cellular processes during cancer progression. MiR-335 has recently been identified to be involved in tumorigenesis of several cancers such as ovarian cancer and gastric cancer. However, the regulation of miR-335 in esophageal squamous cell carcinoma (ESCC) has not been reported yet. METHODS Expression of miR-335 in tumo...