Neeru Gupta*, Chhaya Gupta Department of Pathology, Sri Balaji Action Medical Institute, Paschim vihar, New Delhi, India Xanthogranulomatous oophritis is an unusual chronic inflammatory condition which clinically presents as a mass like lesion in the pelvic cavity. It invades the surrounding tissue and thus mimics like a tumor. Patients with xanthogranulomatous oophoritis presents with lower ab...

A case is described of an autoimmune oophoritis that was diagnosed unexpectedly after a hysterectomy and bilateral salpingo-oophorectomy had been performed on the suspicion of ovarian cysts. The patient was a 43-year-old multiparous woman who presented with vaginal bleeding and lower abdominal pain which she had had for one month. Grossly, the ovaries were enlarged and multicystic. The cysts me...

We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and m...

Female (C57BL/6xA/J)F(1) mice undergoing thymectomy on day 3 after birth (d3tx) developed autoimmune ovarian disease (AOD) and autoimmune disease of the lacrimal gland. As both were prevented by normal adult CD25(+) T cells, regulatory T cell depletion is responsible for d3tx diseases. AOD began as oophoritis at 3 wk. By 4 wk, AOD progressed to ovarian atrophy with autoantibody response against...

Various organ-specific autoimmune diseases can be readily induced in some strains of mice by thymectomy during the critical neonatal period (NTx), 1 on day 2-4 after birth, without any exogenous sensitization with autoantigen (I-4). ~t is assumed in this model that NTx may eliminate T cells that would otherwis6 ontogenically peripherize via the thymus after the day of thymectomy (Tx), and may c...

A 58 year old woman presented with lower abdominal pain and diarrhoea leading to a right hemicolectomy for Crohn's disease. She remained asymptomatic for 23 years until recurrence of disease necessitated resection of 17 cm of ileum. Five years later she developed multiple short Crohn's strictures with fistulae and abscesses into the pelvis. Two areas of ileum measuring 10 cm and 29 cm were exci...