BACKGROUND Tuberculosis remains a serious disease worldwide. Anti-tuberculosis campaigners many times face negative tuberculin skin tests after Bacille Calmette Guérin vaccination. Increasing tuberculin units might be a solution. However, is skin reaction a linear function of tuberculin dose? Are there any side-effects when higher tuberculin doses are administered? CASE PRESENTATION Six simul...

tuberculosis is an important opportunistic disease among hiv- infected persons worldwide; from march 1999 to feburery 2001 we had seventeen patients with hiv-infection and tuberculosis. here we are presenting the clinical manifestations, diagnosis, treatment and outcome of them. all of them were male, 11 patients had pulmonary and 5 patients had extrapulmonary (pleural effusion 1, hepatic granu...

Methods are described for the evaluation in vitro of the effect of tuberculin on the leucocytes of peripheral blood. Washed leucocytes from a tuberculin sensitive host suspended in normal plasma are not lysed by tuberculin until after several hours of contact. Washed leucocytes from a tuberculin-sensitive host slowly release into normal plasma a factor which will cause the lysis of normal leuco...

As we have recently reported (2), in cases of lepromatous leprosy, which almost by defiI1ition are lepromin negative, the administration of BCG causes in some cases an increase in the reactivity to lepromin as well as the usual tuberculin conversions. The following are the data there reported, now slightly revised: One hundred and four lepromatous cases, negative to both tuberculin and lepromin...

background with respect to the prevalence of tuberculosis in our country, bcg vaccination at birth seems to be an effective means of prevention. the present study was designed to evaluate the efficiency of bcg vaccination and factors influencing the tuberculin skin reaction. materials and methods the inoculum of live bcg organisms in vaccinated infants was evaluated at birth and the correlation...

OBJECTIVE The proportion of tuberculin reactors in a population and the intensity of tuberculin reactions have been shown to increase with increasing exposure to mycobacterial infection, eg, repeated BCG immunization. These observations suggested that tuberculin reactivity would become uniformly high in individuals with a high mycobacterial load who did not have a known cause of anergy. Since t...

The method used to produce "Connaught" tuberculin purified protein derivative (PPD) is described. The tuberculin PPD for the multiple-puncture method was shown to be stable for at least 24 months at 5 C; tuberculin PPD for the intracutaneous method was shown to be stable at 5 C and 24 C for a period of 18 months in the presence of Tween 80. Evans blue or brillant vital red was added to tubercul...

T HE TUBERCULIN TEST IS THE MOST effective means for detecting tuberculous infection, and hence is an essential tool in ultimate eradication of the disease. In clinical practice it has been generally accepted that a positive tuberculin skin reaction indicates the possibility of tuberculosis, whereas a negative reaction, with few exceptions, rules out a tuberculous infection. Since the advent of...

The administration of triton WR-1339 (300 mg./kg. subcutaneously) to tuberculin-sensitive guinea pigs 2 hours before the intradermal injection of PPD depresses slightly their skin sensitivity to tuberculin and essentially obliterates the lytic effect of tuberculin on their circulating leucocytes. When leucocytes from tuberculin-sensitive guinea pigs are exposed to triton in vitro at a concentra...