In the form of a case study and based upon novel material about reception Spinoza’s Theological–Political Treatise (TTP) in Iran, this paper studies issues with interactions among political, theological philosophical ideas TTP. The starts first Iranian encounters philosophy Qajar era nineteenth century then focuses on TTP period after 1979 Islamic Revolution. translation was prepared 1990s by M...

This paper outlines the Dutch background of Tractatus theologico-politicus (TTP) and aims to contribute a deeper understanding Theological-Political Treatise. It reads Spinoza’s first main work published anonymously as an intervention in many political-religious controversies, which began 1579 ravaged Republic during century its history. The three topics these controversies are also focus TTP: ...

Tristetraprolin (TTP) is a well-characterized, zinc finger-containing, RNA-binding protein. TTP targets tumor necrosis factor α for degradation via the 3' untranslated region (3'UTR). Although AU-rich elements (AREs) in the 3'UTR of interleukin-6 (IL-6) mRNA dictate mRNA degradation, the role of TTP in the post-transcriptional regulation of IL-6 gene expression is unclear. Here we used TTP-defi...

Tristetraprolin (TTP) is the only trans-acting factor shown to be capable of regulating AU-rich element-dependent mRNA turnover at the level of the intact animal; however, the mechanism by which TTP mediated RNA instability is unknown. Using an established model system, we performed structure/function analysis with TTP as well as examined the current hypothesis that TTP function is regulated by...

Expression of the immediate early protein tristetraprolin (TTP) is induced by numerous stimuli, including tumor necrosis factor-alpha (TNFalpha). Evidence indicates that TTP limits production of TNFalpha and other cytokines by directly binding and destabilizing their mRNAs. This effect seems to require only the conserved TTP zinc finger region, and is characteristic of the related proteins TIS1...

Tristetraprolin (TTP) is an AU-rich element-binding protein that regulates mRNA stability. We previously showed that TTP acts as a negative regulator of VEGF gene expression in colon cancer cells. The p38 MAPK pathway is known to suppress the TTP activity. However, until now the signaling pathway to enhance TTP function is not well known. Here, we show that casein kinase 2 (CK2) enhances the TT...

The mRNA-destabilizing protein tristetraprolin (TTP) negatively regulates adenine- and uridine-rich element (ARE)-containing mRNAs. In A549 pulmonary cells, TTP mRNA and both a approximately 40- and a approximately 45-kDa phosphorylated version of TTP protein were rapidly induced in response to interleukin (IL)-1beta. Analysis with IkappaBalphaDeltaN, a dominant version of inhibitor of kappaBal...

Objective The present study was undertaken to time pregnancy (TTP) and factors associated with TTP in women axial spondyloarthritis (SpA) compared rheumatoid arthritis (RA). Methods We included 274 SpA 317 RA from the Norwegian nationwide registry RevNatus. For all women, we had retrospectively collected data on TTP, a subgroup also prospectively data. using Kaplan‐Meier plots log rank test. To...