نتایج جستجو برای: ttga
تعداد نتایج: 55 فیلتر نتایج به سال:
BACKGROUND & AIMS Little is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area. METHODS We collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diab...
OBJECTIVES There are significant geographical differences in the prevalence and incidence of celiac disease that cannot be explained by HLA alone. More than 40 loci outside of the HLA region have been associated with celiac disease. We investigated the roles of these non-HLA genes in the development of tissue transglutaminase autoantibodies (tTGA) and celiac disease in a large international pro...
سابقه و هدف: با وجود شیوع بالای بیماری سلیاک در بیماران مبتلا به دیابت نوع 1 در چندین مطالعه غیر ایرانی، این موضوع در کشورمان کمتر بررسی شده است. هدف این مطالعه بررسی شیوع بیماری سلیاک در بین بیماران مبتلا به دیابت نوع 1 در شمال غرب ایران با استفاده از آزمون آنتی بادی ترانس گلوتامیناز بافتی (tTGA) است.روش بررسی: در این مطالعه مورد-شاهدی، 100 بیمار دیابتی نوع1 و 150 فرد سالم بدون سابقه دیابت، بی...
The TTGA-binding factor is a transcriptional regulator activated by DIF, the chlorinated hexaphenone that induces prestalk cell differentiation in Dictyostelium. The same activity also functions as a repressor, controlling stalk cell differentiation. We show that the TTGA-binding factor is a STAT protein. Like the metazoan STATs, it functions via the reciprocal interaction of a phosphotyrosine ...
BACKGROUND AND OBJECTIVES Psychological symptoms can be associated with celiac disease; however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a...
OBJECTIVE To compare the frequency of celiac disease (CD) in patients with multiple sclerosis (MS) and healthy controls using tissue transglutaminase IgA antibodies (anti-tTGA) as a screening tool. BACKGROUND CD and MS are immune-mediated diseases, and it has been hypothesized that the genetic similarities between these conditions can predispose individuals to suffer from both. Data regarding...
OBJECTIVE Histological evaluation of intestinal biopsies for the diagnosis of coeliac disease can be challenging and compatible with risk of misdiagnosis. The aim was to evaluate the agreement of pathological diagnosis for coeliac disease in children investigated at four major paediatric university hospitals in Sweden. MATERIALS AND METHODS Intestinal duodenal biopsies were collected from 402 c...
زمینه و هدف: همراهی سلیاک و دیابت با عوارض متعدد در کودکان همراه است و در صورت عدم تشخیص به‌موقع در کودکان دیابتی عوارض ناشی از سلیاک شامل اختلالات گوارشی، کاهش اشتها و آسیب ناشی از هایپوپروتئینمی و از همه مهم‌تر اختلال رشد بروز می‌کند. این مطالعه با هدف مقایسه فراوانی سلیاک در کودکان دیابتی زیر 15 سال با گروه شاهد مراجعه‌کننده به کلینیک‌های وابسته به دانشگاه علوم پزشکی شهرکرد انجام شد. روش بر...
BACKGROUND Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is an important risk factor for the occurrence of diabetes complications. The prevalence of celiac disease (CD) is high in type 1 diabetes mellitus however, there are scarce data a...
Objective Concomitant non-alcoholic fatty liver disease (NAFLD) and coeliac disease (CD) have not been adequately studied. This study investigated the frequency of CD among NAFLD patients and the clinicopathological and immunological patterns and outcome of concomitant NAFLD and CD. Design This prospective longitudinal study screened patients with NAFLD for CD (tissue transglutaminase antibod...
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