نتایج جستجو برای: ttg

تعداد نتایج: 923  

Journal: :Circulation research 2006
Erik N T P Bakker Adrian Pistea Jos A E Spaan Titia Rolf Carlie J de Vries Nico van Rooijen Eleonara Candi Ed VanBavel

Chronic changes in blood flow induce an adaptation of vascular caliber. Thus, arteries show inward remodeling after a reduction in blood flow. We hypothesized that this remodeling depends on the crosslinking enzyme tissue-type transglutaminase (tTG). Flow-dependent remodeling was studied in wild-type (WT) and tTG-null mice using a surgically imposed change in blood flow in small mesenteric arte...

Journal: :International journal of clinical and experimental pathology 2011
Gang Zhao Zhi-Qi Zhang Bin Zhang Meng Luo Yong-Wei Sun Zhi-Yong Wu

PURPOSE Expressed in hepatic stellate cell (HSC), tTG is involved in fibrotic diseases including human hepatic fibrosis by promoting the cross-linking of ECM and participating in the initiation and/or progression of liver fibrosis. The purpose of this study is to identify whether depletion of tTG could attenuate liver fibrosis. METHODS In this study, primary hepatic stellate cells were isolat...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999
L Piredda M G Farrace M Lo Bello W Malorni G Melino R Petruzzelli M Piacentini

Overexpression of 'tissue' transglutaminase (tTG) in the human neuroblastoma cells increases spontaneous apoptosis and renders these cells highly susceptible to death induced by various stimuli. We used immunoprecipitation to identify cellular proteins that interact specifically with tTG in SK-N-BE(2) -derived stable transfectants. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analy...

Journal: :The Biochemical journal 2003
Carla Esposito Monica Marra Gaia Giuberti Anna Maria D'Alessandro Raffaele Porta Anna Cozzolino Michele Caraglia Alberto Abbruzzese

The addition of 2500 i.u./ml interferon alpha (IFNalpha) for 48 h induced apoptosis, and caused an approx. 4-fold increase in the activity and expression of tissue transglutaminase (tTG), in human lung cancer H1355 cells. However, the increase in mRNA levels for tTG was just 1.6-fold. On the basis of these data, we investigated whether tTG levels may be regulated through regulation of its degra...

2016
Alberto Rubio-Tapia Jonas F. Ludvigsson Rok Seon Choung Tricia L. Brantner S. Vincent Rajkumar Ola Landgren Joseph A. Murray

BACKGROUND Immunoglobulin A (IgA) antibodies to tissue transglutaminase (tTG) are the serologic test of choice for diagnosing celiac disease (CD). Our aim was to determine if elevated IgA anti-tTG were associated with increased mortality risk. METHODS Stored serum samples of National Health and Nutrition Examination Survey (NHANES) III (1988-1992) were available for 6032 individuals aged 50 y...

Journal: :The American journal of physiology 1998
Gerald S Kuncio Mariya Tsyganskaya Jianling Zhu Shu-Ling Liu Laszlo Nagy Vilmos Thomazy Peter J A Davies Mark A Zern

One of several postulated roles for tissue transglutaminase (tTG) is the stabilization and assembly of extracellular matrix via peptide cross-linking. We previously determined that tTG activity increased in an animal model of hepatic fibrogenesis and in human liver disease. To further study the role of tTG in liver disease, we initiated investigations into the effect of a proinflammatory mediat...

2014
Chung-Hoon Kim Jun-Woo Ahn Jei-Won Moon Sung-Hoon Kim Hee-Dong Chae Byung-Moon Kang

This study was performed to investigate the effect of of transdermal testosterone gel (TTG) on controlled ovarian stimulation (COS) and IVF outcomes and ovarian morphology according to pretreatment duration in poor responders. A total of 120 women were recruited for this pilot study. They were randomized into control, 2 weeks, 3 weeks or 4 weeks TTG treatment groups. For three TTG treatment gro...

Journal: :Gut 2001
A Carroccio L Giannitrapani M Soresi T Not G Iacono C Di Rosa E Panfili A Notarbartolo G Montalto

BACKGROUND It has been suggested that serological screening for coeliac disease (CD) should be performed in patients with chronic unexplained hypertransaminasaemia. AIMS To evaluate the specificity for CD diagnosis of serum IgA antitissue transglutaminase (tTG) determination in consecutive patients with chronic hypertransaminasaemia using the most widely utilised ELISA based on tTG from guine...

2009
Vincenzo Villanacci Tarcisio Not Daniele Sblattero Tiziano Gaiotto Fernando Chirdo Anna Galletti Gabrio Bassotti

Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies to tTG are a diagnostic marker of gluten-sensitive enteropathy. The aim of this study was to investigate the localization of tTG in the duodenal mucosa in control tissues and in different histological stages of celiac disease by using a commercial and a novel set of anti-tTG monoclonal antibodies...

Journal: :Gut 2003
W Dieterich D Trapp B Esslinger M Leidenberger J Piper E Hahn D Schuppan

BACKGROUND AND AIMS Coeliac disease (CD) is characterised by the presence of autoantibodies against tissue transglutaminase (tTG), the endomysial autoantigen. This study was performed to determine the effect of purified autoantibodies on the enzymatic activity of tTG. METHODS Total IgA and IgG class antibodies and purified anti-tTG autoantibodies were isolated from sera of untreated patients ...

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