This study describes the development, field utility, reliability, and validity of the multidimensional Tool for Risk, Interventions, and Outcomes (TRIO) for use in Adult Protective Services (APS). The TRIO is designed to facilitate consistent APS practice and collect data related to multiple dimensions of typical interactions with APS clients, including the investigation and assessment of risks...

The Rho GTPases RhoA and Rac1 function as master regulators of cytokinesis by controlling the actomyosin cytoskeleton. RhoA and Rac1 have to be respectively activated and inactivated at the division plane for cytokinesis to occur properly. The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP. However, the guanine-nucleotide exchange factor (GEF) that activates Rac1 during ...

Abl tyrosine kinase and its effectors among the Rho family of GTPases each act to control dendritic morphogenesis in Drosophila. It has not been established, however, which of the many GTPase regulators in the cell link these signaling molecules in the dendrite. In axons, the bifunctional guanine exchange factor, Trio, is an essential link between the Abl tyrosine kinase signaling pathway and R...

The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediates Rac1 activation in netrin-1 signaling. We found that Trio interacts with the netrin-1 receptor...

AIM To use a virtually simulated population, generated from published allele frequencies based on 15 short tandem repeats (STR), to evaluate the efficacy of trio sibship testing and sibling assignment for forensic purposes. METHODS Virtual populations were generated using 15 STR loci to create a large number of related and unrelated genotypes (10,000 trio combinations). Using these virtual po...

Perinatal mortality is a major issue in laboratory mouse breeding. We compared counting method using daily checks (DAILY_CHECK) with combining detailed video analyses to detect cannibalisms (VIDEO_TRACK) for estimating the number of C57BL/6 pups that were born, died and weaned 193 litters from trios (TRIO-OVERLAP) or without (TRIO-NO_OVERLAP) presence another litter. Linear mixed models used at...

We demonstrate the efficiency of the multidomain sampler (MDS) in finding multiple distinct global minima and low-energy local minima in the hydrophobic-polar (HP) lattice protein model. Extending the idea of partitioning energy space in the Wang-Landau algorithm, our approach introduces an additional partitioning scheme to divide the protein conformation space into local basins of attraction. ...

Description Testing SNPs and SNP interactions with a genotypic TDT. This package furthermore contains functions for computing pairwise values of LD measures and for identifying LD blocks, as well as functions for setting up matched case pseudo-control genotype data for case-parent trios in order to run trio logic regression, for imputing missing genotypes in trios, for simulating case-parent tr...

Biomuse Trio is a composition for biomuse, violin and laptop. The strengths of each instrument are fused into a chamber music composition that emphasizes precise, coordinated musical interaction. There is a particular interest to explore the human body as musical instrument, and thus the various prosthetics of the Biomuse are hidden in performance.