background: influenza outbreak has become a great lifethreateningdisease in the world. nasal vaccines can inducesystemic igg and mucosal iga antibody responses, whichestablish two layers of immune defense against the infectiouspathogens like influenza. mucosal vaccines must overcomeseveral limitations, including the mucociliary clearance andinefficient uptake of soluble antigens. therefore, nas...

objective(s): an efficient vaccine against tb is an urgent need. tb peptides are safe candidate but they are weak immunogens and needs to be potentiated by adjuvant/delivery systems. the main purpose of the present study was to determine the potential of cht based nps containing esat-6 antigen of m. tuberculosis for inducing mucosal and systemic immune responses after intranasal and subcutaneou...

BACKGROUND & OBJECTIVES With the current snags from the use of Artemisinin - combination therapies (ACTs) in malaria treatment in addition to fear of cross- resistance to unrelated drugs, raising the immunocompetence of individuals in malaria endemic areas by vaccination is the best approach to malaria - free world. METHODS Water - soluble cationic derivative, N, N, N- trimethylchitosan (TMC)...

Vaccination is considered to be most effective way of fighting infectious diseases like malaria etc [1]. N, N, N-trimethylchitosan (TMC) was synthesized from chitosan. Nanoparticles of the TMC were prepared in various media (milliQ water, Na2CO3 (pH 10.92), Na2HPO4 (pH 9.01) and alhydrogel beads which were characterized as adjuvant for possible vaccine delivery. The nanoparticles were analyzed ...

Objective(s): Drug delivery via mucosal routes has been confirmed to be effective in inducing strong immune responses. Liposomes could enhance immune responses and mucoadhesive potentials, make them useful mucosal drug delivery systems. Coating of liposomes by mucoadhesive polymers succeeded in enhancing immune responses. Our studies aim at preparation and characterization of trimethylchitosan-...

Development of effective non-viral vectors is of crucial importance in the implementation of RNA interference in clinical routine. The localized delivery of siRNAs to the gastrointestinal mucosa is highly desired but faces specific problems such as the stability in gastric acidity conditions and the presence of the mucus barrier. CDX2 is a transcription factor critical for intestinal differenti...