نتایج جستجو برای: trimerization

تعداد نتایج: 507  

Journal: :Molecular cell 2016
Qingshan Fu Tian-Min Fu Anthony C Cruz Prabuddha Sengupta Stacy K Thomas Shuqing Wang Richard M Siegel Hao Wu James J Chou

Fas (CD95, Apo-1, or TNFRSF6) is a prototypical apoptosis-inducing death receptor in the tumor necrosis factor receptor (TNFR) superfamily. While the extracellular domains of TNFRs form trimeric complexes with their ligands and the intracellular domains engage in higher-order oligomerization, the role of the transmembrane (TM) domains is unknown. We determined the NMR structures of mouse and hu...

Journal: :Journal of bacteriology 1991
K Sen H Nikaido

Deep rought mutants, which produce very defective lipopolysaccharides, are unable to export normal levels of porins into the outer membrane. In this study, we showed that lipopolysaccharides from such mutants were also unable to facilitate the trimerization, in vitro, of monomeric OmpF porin secreted by spheroplasts of Escherichia coli B/r. In contrast, lipopolysaccharides containing most or al...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Felix Tritschler Joerg E Braun Carina Motz Catia Igreja Gabrielle Haas Vincent Truffault Elisa Izaurralde Oliver Weichenrieder

DCP1 stimulates the decapping enzyme DCP2, which removes the mRNA 5' cap structure committing mRNAs to degradation. In multicellular eukaryotes, DCP1-DCP2 interaction is stabilized by additional proteins, including EDC4. However, most information on DCP2 activation stems from studies in S. cerevisiae, which lacks EDC4. Furthermore, DCP1 orthologs from multicellular eukaryotes have a C-terminal ...

2017
Emily J Furlong Alvin W Lo Fabian Kurth Lakshmanane Premkumar Makrina Totsika Maud E S Achard Maria A Halili Begoña Heras Andrew E Whitten Hassanul G Choudhury Mark A Schembri Jennifer L Martin

Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized proteins in this family, it is trimeric. PmScsC trimerization and its active si...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Philip R Tedbury Mariia Novikova Sherimay D Ablan Eric O Freed

The matrix (MA) domain of HIV Gag has important functions in directing the trafficking of Gag to sites of assembly and mediating the incorporation of the envelope glycoprotein (Env) into assembling particles. HIV-1 MA has been shown to form trimers in vitro; however, neither the presence nor the role of MA trimers has been documented in HIV-1 virions. We developed a cross-linking strategy to re...

Journal: :The Journal of general virology 2005
Ludmilla Sissoëff Mohamed Mousli Patrick England Christine Tuffereau

Native rabies virus glycoprotein (RVGvir) is a trimeric, membrane-anchored protein that has been shown to interact with the p75NTR neurotrophin receptor. In order to determine if the RVG trimeric oligomerization state is required for its binding with p75NTR, different soluble recombinant molecules containing the entire RVG ectodomain (RVGect) were expressed alone or fused at its C terminus to t...

Journal: :Journal of virology 2006
Jiali Li Sonya Lad Guang Yang Yunping Luo Milena Iacobelli-Martinez F James Primus Ralph A Reisfeld Erguang Li

Adenoviral (Ad) vectors have been widely used in human gene therapy clinical trials. However, their application has frequently been restricted by the unfavorable expression of cell surface receptors critical for Ad infection. Infections by Ad2 and Ad5 are largely regulated by the elongated fiber protein that mediates its attachment to a cell surface receptor, coxsackie and adenovirus receptor (...

Journal: :Chemical communications 2004
Giovanni Bottari Tomás Torres

The first benzene-centered, phthalocyanine hexamer has been synthesized by a dicobaltoctacarbonyl-catalyzed trimerization reaction of an ethynyl-bridged bisphthalocyanine and characterized by different spectrometric and spectroscopic techniques.

Journal: :iranian journal of chemistry and chemical engineering (ijcce) 2009
m. majid heravi sodeh sadjadi rahim hekmatshoar hossein abdi oskooie fatemeh bamoharram

the catalytic air oxidation-trimerization of alcohols was carried out with hetropolyacids. in the presence of hetropolyacid formation of cyclotrimers of alcohols and aldol condensation products was observed. the 1,3,5-trioxanes were major and aldol condensation compounds were minor products.

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