BACKGROUND/AIM This study investigates whether 1-(2-trifluoromethylphenyl)-imidazole (TRIM), originally proposed as a nitric oxide synthase inhibitor and also suggested to be an inhibitor of store-operated calcium entry in mouse anococcygeal muscle, inhibits receptor-independent and -dependent responses in rat thoracic aorta. MATERIALS AND METHODS Cyclopiazonic acid- and serotonin-induced vas...

A solid board factory produces rectangular sheets of cardboard in two different formats, namely large formats and small formats. The production process consists of two stages separated by an inventory point. In the first stage a cardboard machine produces the large formats. In the second stage a part of the large formats is cut into small formats by a separate rotary cut machine. Due to very la...

This paper presents TRIM+, an architecture for transparent mobility management with route optimization in IMS based networks. The design of our architecture is based on a previous work referred to as TRIM. TRIM was originally devised to provide transparent mobility support in the IMS, although transparency came at the cost of using a suboptimal data path between communicating end points. TRIM+ ...

Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral immunity. The TRIM family is ancient and has been greatly diversified in vertebrates and especially in fish. We analyzed the complete sets of ...

OBJECTIVE The disinhibition scale of the Eating Inventory predicts weight loss outcome; however, it may include multiple factors. The purpose of this study was to examine the factor structure of the disinhibition scale and determine how its factors independently relate to long-term weight loss outcomes. RESEARCH METHODS AND PROCEDURES Exploratory factor analysis of the disinhibition scale was...

Fine paper mills produce a variety of paper grades to satisfy demand for a large number of sheeted products. Huge reels of different paper grades are produced on a cyclical basis on paper machines. These reels are then cut into rolls of smaller size which are then either sold as such, or sheeted into finished products in converting plants. A huge number of roll sizes would be required to cut al...

A two-dimensional t r i m l o s s problem is con­ sidered in which the c u t t i n g is two-stage but there are c o n s t r a i n t s on the sequencing of the c u t t i n g of o rde rs , A method is developed in which problem reduc t i on is used to generate a set of poss ib le c u t t i n g pa t te rns at each step and an h e u r i s t i c choice made of a p a t t e r n from tha t s e t . The ...

In this paper, we address the combined assortment and trim loss minimization problem. In real settings, when different stock lengths are available, a common problem is to select a subset of stock lengths from which to cut the ordered items. In the cutting and packing literature, this problem is known as the assortment problem. Solving the assortment and trim loss minimization problem in a singl...

Thymic selection is a tightly regulated developmental process essential for establishing central tolerance. The intensity of TCR-mediated signaling is a key factor for determining cell fate in the thymus. It is widely accepted that low-intensity signals result in positive selection, whereas high-intensity signals induce negative selection. Transmembrane adaptor proteins have been demonstrated t...