The thyroid hormone is responsible for regulating the metabolic rate of every cell in the body. The action of thyroid hormone is very important in many developmental processes such as body growth and central nervous system maturation. When the thyroid gland is malfunctioning, it can affect anysystem of the body including auditory system [1]. Thyroid disorder is a general term representing sever...

Metabolic hormones such as insulin and thyroid hormones play an important role in animal metabolism. Insulin is a 5.8-kDa protein synthesized in the pancreatic β-cells and secreted in response to evaluation of plasma glucose level (Magistrelli et al., 2008). Insulin has an important role in glucose transport and modulates peripheral satiety signals and directly targets the central nervous syste...

There have been suggestions that the genetically obese rat has abnormal thyroid function [1,2]. It is also known that while the obese rat shows various physiological and metabolic abnormalities normally associated with hypothyroidism, it also has other defects that are not generally found in hypothyroid animals. Like the hypothyroid rat, which shows decreased oxygen consumption in adipose tissu...

Objective: Sudden exposure to high iodide levels may cause thyroid dysfunction. Although the iodinated contrast medium used for computed tomography and coronary angiography is known to alter thyroid function, the water-soluble iodinated contrast medium (ICM) used for hysterosalpingography (HSG) has not been investigated comprehensively. In the present study, we aimed to investigate the effect o...

Perfluoroalkyl substances (PFASs) have been detected in wildlife and human samples worldwide. Toxicology research showed that PFASs could interfere with thyroid hormone homeostasis. In this study, eight PFASs, fifteen PFAS precursors and five thyroid hormones were analyzed in 157 paired maternal and cord serum samples collected in Beijing around delivery. Seven PFASs and two precursors were det...

BACKGROUND Thyroid function test results of healthy pregnant women differ from those of healthy non-pregnant women. This study aimed to determine trimester-specific reference ranges for total tetraiodothyronin (T4), free T4, total triiodothyronin (T3) and thyroid stimulation hormone (TSH) using electrochemiluminescence techniques from apparently healthy pregnant women in Basrah. MATERIAL AND ...

This study aimed to evaluate the anti-inflammatory effects of Annona squamosa (A. squamosa) leaf aqueous extract against acetic acid induced colitis in rats with a trial to explore its use for the treatment of colon inflammation. Sprague Dawley rats weighing 180-200 g were used in this study. Treatment with A. squamosa extract at dose 300 mg/kg for 4 weeks counteracted acetic acid induced ulcer...

OBJECTIVE This study aimed to assess the iodine deficiency, prevalence of goitre among schoolchildren and measuring environmental iodine in Taif city, Saudi Arabia. METHODS A cross-sectional multistage cluster-sampling methodology was done on 1887 schoolchildren. Their urinary iodine concentration (UIC) and goitre prevalence was assessed. Blood level of triiodothyronin, thyroxine and thyroid-...

The metabolism of 3, 5-[3'-125I]triiodothyronin (T3) and 3-[3', 5'-125I]triiodothyronine (rT3) was studied in cultured monkey hepatocarcinoma cells (NCLP-6E), and the deiodinations of these iodothyronines were also investigated in cultured cell homogenates and in rat liver homogenates. The metabolites were analyzed by ion exchange column chromatography. For nonphenolic ring deiodination of 3, 5...