Since the introduction of monoamine oxidase inhibitors (MAOIs) in the 1950s, researchers have been searching for antidepressant agents with more favorable tolerability profiles. The introduction of selective serotonin reuptake inhibitors (SSRIs) in the late 1980s provided clinicians with a drug class featuring an improved tolerability profile as compared to MAOIs and tricyclic antidepressants (...

Submit Manuscript | http://medcraveonline.com Abbreviations: TCAs: Tricyclic Antidepressants; SSRIs: Selective Serotonin-Reuptake Inhibitors; MAOIs: Monoamine Oxidase Inhibitors; SNRI: Serotonin-Norepinephrine Reuptake Inhibitor; PMDD: Premenstrual Dysphoric Disorder; SAD: Seasonal Affective Disorder; PMS: Premenstrual Syndrome; NE: Norepinephrine; 5-HT: 5-Hydroxytryptamine; DA: Dopamine; CNS: ...

Tricyclic antidepressants (TCAs) are among the most effective antidepressants available, although their poor tolerance at usual recommended doses and toxicity in overdose make them difficult to use. While selective serotonin reuptake inhibitors (SSRIs) are better tolerated than TCAs, they have their own specific problems, such as the aggravation of sexual dysfunction, interaction with coadminis...

BACKGROUND Although depression and chronic pain frequently co-occur, there is a lack of clarity in the literature regarding the cost-effectiveness and cost-utility of antidepressants in the presence of these two conditions. From the perspective of healthcare provider, the current study aims to compare the cost-effectiveness and cost-utility of antidepressants in a national cohort of depressed p...

Noradrenaline has long played a key role in the way the etiology of depression is conceptualized and in the mechanism of action of many current antidepressants. Tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), serotonin-noradrenaline reuptake inhibitors (SNRIs), selective noradrenaline reuptake inhibitors (NRIs), the noradrenergic and specific serotonergic antidepressant ...

■ ■ Compatibility with SPE eluate for direct injection IN T RODUC T ION Although tricyclic antidepressants (TCAs) are an older class of drug, they remain pharmacologically relevant. For example, inadequate response to other classes of antidepressants in dosed subjects remains common, ensuring the continued viability of TCAs. Furthermore, the fact that they are significantly less expensive than ...

Tricyclic antidepressants (TCAs) include imipramine, desipramine, amitriptyline, nortriptyline, doxepin, trimipramine, protriptyline, and clomipramine 1) . Among these, imipramine was first synthesized in 1948. However, it was not until 1958 that its antidepressant affects in humans were recognized. Since then, it has been the prototype TCA. Imipramine is used for the treatment of non-bipolar d...

Prevalence of tricyclic antidepressants (TCAs) has not been explored in pilots. The National Transportation Safety Board (NTSB) aviation accident and the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) toxicology and medical certification databases were searched for pilots fatally injured in aviation accidents. During 1990-2012, CAMI received bio-samples of pilots fro...

Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned wit...

Introduction: Tricyclic antidepressants (TCAs) are widely used in psychiatric and medical conditions and are a major cause of drug overdoses and fatal poisonings in many contries. Sodium bicarbonate administration is widely recommended as the first line treatment in TCAs intoxication but the best method of its administration has not been yet established therefore, we decided to compare the ef...