In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions of phosphorylation in ICP0 (amino acids 224 to 232, 365 to 371, and 508 to 518) have been identified, and mutant viruses that block phosphorylation ...

From literature data on partition coefficients and in some cases solubilities in nonaqueous solvents we have been able to determine Abraham descriptors for several series of organophosphorus compounds including the dialkyl- and diaryl-phosphates (dialkylphosphoric acids), trialkyl- and triphenyl-phosphates, dialkylphosphinic acids and diphenylphosphinic acid, trialkyl- and triaryl-phosphine oxi...

The accumulation of nutrients (eutrophication) in water bodies generally produces increased concentrations organic matter that eventually are deposited sediment, and partially mineralized, generating greenhouse carbon gases (GHCG). application eutrophication control methods includes the phosphate adsorbing materials such as Phoslock (PHOS), hypolimnetic oxygenation systems (HOS). We evaluated g...

The adducts produced in the reaction between trialkyl phosphites and acetylenic esters were trapped by hydantoins to produce highly functionalized dialkyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl) succinate in good yields.

Background: Public health officers (PHOs) are the frontline workforce against Coronavirus disease 2019 (COVID-19) and therefore need high immunity for protection. The application of capability, opportunity, motivation, behavior (COM-B) model aimed to 1) explore level COM-B prevention control COVID-19, 2) analyze association between factors behaviors COVID-19 among PHOs at primary care units (PC...

Iron oxide magnetic nanoparticles were synthesized with different sizes (11 and 30 nm). Subsequently they shelled a silica layer allowing grafting of an organic phosphine ligand that coordinated to the [MoI2(CO)3] organometallic core. The was prepared by Stöber method using either mechanical (both 11 nm nanoparticles) or ultrasound (30 only) stirring. latter once coated obtained less aggregatio...

A series of structurally related antiviral antibiotics, fluvirucins A1, A2, B1, B2, B3, B4 and B5 have been isolated from the fermentation broths of five unidentified actinomycete isolates. Based on spectroscopic analysis, partial degradation experiments and 13C-enriched acetic acid-fed biosynthetic studies, their structures were elucidated to be 2.6,10-trialkyl-3(or 9)-aminoglycosyl-13-trideca...