AIMS Intestinal trefoil factor is a mucosa associated trefoil peptide expressed predominantly in the goblet cells of the small and large intestine. The aim of this work was to investigate the expression of the intestinal trefoil factor gene in human colorectal cancers. METHODS The expression of intestinal trefoil factor mRNA was examined by northern blot analysis in 27 cases of surgically res...

As part of a study to evaluate alternative forages for farmed deer, we compared forage yields and quality of birdsfoot trefoil (Lotus corniculatus) and forage chicory (Cichorium intybus) with that of alfalfa (Medicago sativa) in north central Alberta, Canada. Despite similar plant densities among the three species, the foliar cover of chicory averaged 76%, 20% greater than alfalfa and 50% great...

Healing of mucosal damage takes place in two phases: restitution of mucosal integrity and remodeling towards recreating the original glandular arrangements. These processes can be observed in several experimental rodent models: e.g., cryoprobe or NSAID-generated ulcers in the gastric or duodenal mucosa and following surgical resection of the small or large bowel. In some studies, it has been po...

This article describes on-going work using an object-oriented database, P/FDM, to build 3D homology models of β-trefoil proteins such as Interleukin-1 (IL-1), by exploiting existing structural data from known structures of the same fold. The model-building procedure is based on the powerful querying capabilities of P/FDM that allows data access, navigation, and computation to be mixed freely an...

AIM To compare the optical outcomes of biaxial microincision cataract surgery (B-MICS) versus coaxial small-incision cataract surgery (C-SICS). METHODS Thirty patients (sixty eyes) with bilateral age-related cataract underwent B-MICS through a 1.7 mm clear corneal incision (CCI) in one eye and C-SICS through a 2.8-mm CCI in the other eye. Every eye was implanted with a micro-incision aspheric...

The shallow lateral recesses of the trefoil shape of the lumbar spinal canal have been implicated in the production of the spinal stenosis syndrome. In the present study, 485 skeletons of South African Blacks and Whites were examined in order to establish the incidence and possible genesis of the trefoil configuration. The overall incidence was 14 per cent, with little variation between the sex...

It is well-known that acetylsalicylic acid induces gastrointestinal complication. Recently, trefoil factor family has been reported as a mucosal protective factor. We focused on trefoil factor family as one of defensive system for gastrointestinal injuries. The aim of this trial was to evaluate trefoil factor family levels in the serum of healthy subjects with low-dose acetylsalicylic acid. Low...

BACKGROUND When the concentrations of 2 or more substances are measured separately, their molar ratios are subject to the additive imprecisions of the different assays. We hypothesized that the cumulative error for concentration ratios of peptides containing a common sequence might be minimized by measuring the peptides simultaneously with a "trefoil-type" immunoassay. METHODS As a model of t...