Treatment of dominantly inherited muscle disorders remains a difficult task considering the need to eliminate the pathogenic gene product in a body-wide fashion. We show here that it is possible to reverse dominant muscle disease in a mouse model of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a common form of muscular dystrophy associated with a complex cascade of epigenetic events f...

BACKGROUND Medical research strives to improve health; community-engaged research (CEnR) supports translation to the community. METHODS This article describes the use of andragogical theory to develop asynchronous CEnR training. RESULTS A total of 43 researchers and community members completed at least one module. The majority (67%-100%) stated that training met their educational needs and ...

Community-based participatory research (CBPR) has emerged in the last decades as a transformative research paradigm that bridges the gap between science and practice through community engagement and social action to increase health equity. CBPR expands the potential for the translational sciences to develop, implement, and disseminate effective interventions across diverse communities through s...

Changes in technology are fundamentally reframing our concept of what constitutes a model organism. Nevertheless, research advances in the more traditional model organisms have enabled fresh and exciting opportunities for young scientists to establish new careers and offer the hope of comprehensive understanding of fundamental processes in life. New advances in translational research can be exp...

Laboratory research recently has greatly enhanced the understanding of placebo and nocebo effects by identifying specific neuromodulators and brain areas associated with them. However, little progress has been made in translating this knowledge into improved patient care. Here, we discuss the limitations in our knowledge about placebo (and nocebo) effects and the need for translational research...

background: diabetic retinopathy is the major cause of blindness among working-age population across the world. despite the urgent need for research strategic planning in this field, no systematic research has been previously performed analyzing the published research on diabetic retinopathy. the study aimed to analyze the scientific productions on dr for drawing a general roadmap for future re...