Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...

Ultradeformable vesicles (UDV) have recently become a promising tool for the development of improved and innovative dermal and transdermal therapies. The aim of this work was to study three related UDV: transfersomes, ethosomes, and transethosomes for the incorporation of actives of distinct polarities, namely, vitamin E and caffeine, and to evaluate the effect of the carrier on skin permeation...

Methotrexate on its oral and intravenous administration results in unwanted adverse effects. This drawback can be overcome by transdermal delivery because of painless objective for systemic drug administration. Transfersomes are ultra-deformable vesicles with the flexibility to reach deeper tissues skin. The this research work was develop methotrexate transfersomal gel thin film hydration techn...

The delivery of drugs and active agents to the skin by formulations containing nanoparticles is a topic of considerable current interest. A number of studies have shown important advantages of these nanostructure-based delivery systems over conventional formulations. This review describes the composition, preparation, and characteristics of a wide range of novel vectors, including nanoemulsions...

Novel formulations of the halogenated corticosteroid, triamcinolone-acetonide, based on ultradeformable mixed lipid vesicles, Transfersomes, are described. Their performance was tested in vivo using radioactive label measurements, to study the drug biodistribution, and murine ear edema, to determine the drug bioactivity. Sparse use of drug-loaded Transfersomes on the skin ensures an almost excl...

The aim of this study was to improve the transdermal permeation of Diclofenac sodium, a poorly water-soluble drug, employing conventional liposomes, ethosomes, and transfersomes. The prepared formulations had been characterized for the loaded drug amount and vesicle size. The prepared vesicular systems were incorporated into 1% Carbopol 914 gel, and a survey of in vitro drug release and drug re...

The turn of century has witnessed a huge increase in the number of technologies and immunological approaches for new vaccine design. Vesicular carriers, i.e. liposomes, niosomes, transfersomes represent widely exploited class of novel delivery systems for topical applications. Non-invasive vaccination onto the skin using these novel carriers could improve vaccination programs because the proced...