In the June 1, 1991 issue of Blood, Cochran et all found that the primary pathway for initial uptake of AI-transferrin and Fetransferrin by human fetal red cells (obtained from placentas) was through a high-affinity saturable receptor that did not distinguish between the two metallo-transferrins; that a process that followed initial uptake did distinguish between the two metallo-transferrins; a...

The autoantibodies found in human and murine systemic lupus erythematosus (SLE) are generally directed against cells or components of cells such as nuclear antigens. This predilection may be due to the unusual immunogenicity of certain autoantigens, or to unusual patterns of antibody crossreactivity. Alternatively, the observed spectrum of reactivities may reflect the in vivo absorption of thos...

Investigations of the cattle karyotypes in the progeny groups of sires, heterozygous for a translocation of centric fusion type and back-crossed to normal dams, showed a deficient number of heterozygotes. As the ratio in the calves was approximately 1: 1 the deficiency in the total back-cross progeny, significant on the 95 per cent level, might have been due to selection against sexually mature...

ENETICALLY controlled differences in the p-globulins of British breeds of Gdairy cattle have been described by SMITHIES and HICKMAN (1958) and ASHTON (1958). GIBLETT, HICKMAN and SMITHIES (1959) showed that these ,@globulins are transferrins. The same transferrin differences have been described in Swedish cattle (GAHNE, RENDEL and VENGE 1960) and in Danish cattle ( H~JGAARD, MOUSTGAARD and M ~ ...

During endochondral bone formation, avascular cartilage differentiates to hypertrophic cartilage that then undergoes erosion and vascularization leading to bone deposition. Resting cartilage produces inhibitors of angiogenesis, shifting to production of angiogenic stimulators in hypertrophic cartilage. A major protein synthesized by hypertrophic cartilage both in vivo and in vitro is transferri...