Unlike typical cis-splicing, trans-splicing joins exons from two separate transcripts to produce chimeric mRNA and has been detected in most eukaryotes. Trans-splicing in trypanosomes and nematodes has been characterized as a spliced leader RNA-facilitated reaction; in contrast, its mechanism in higher eukaryotes remains unclear. Here we investigate mod(mdg4), a classic trans-spliced gene in Dr...

*Correspondence: Xiaojing Liu, School of Nuclear Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China e-mail: [email protected] During the loss of coolant accident (LOCA) of supercritical water-cooled reactor (SCWR), the pressure in the reactor system will undergo a rapid decrease from the supercritical pressure to the subcritical condition. T...

Airfoil fin printed circuit heat exchangers (PCHEs) have broad application prospects in the naval, aerospace, electric power, and petrochemical industries. The channel structure is a critical factor affecting their thermal-hydraulic characteristics. In this study, novel PCHE with staggered NACA 0025 airfoil-shaped fins was proposed; accordingly, characteristics of using carbon dioxide as workin...

Prospective studies of the potential health consequences of trade and investment treaties, such as the Trans-Pacific Partnership, are critical. These studies can make visible to trade policy-makers the potential negative impacts associated to such treaties and can influence the outcomes of such negotiations. However, few researchers have examined retrospectively the consequences of trade agreem...

The trans-catheter valve-in-valve concept has become a feasible therapeutic option for patients with failing degenerated bioprosthesis, who are deemed inoperable. However, little is known about the feasibility of this technique in failed valve annuloplasty. We report the first-in-man implantation of a trans-catheter aortic valve within a mitral annuloplasty ring. Through a trans-apical trans-ca...

Since accurate translation from mRNA to protein is critical to survival, cells have developed translational quality control systems. Bacterial ribosomes stalled on truncated mRNA are rescued by a system involving tmRNA and SmpB referred to as trans-translation. Here, we review current understanding of the mechanism of trans-translation. Based on results obtained by using directed hydroxyl radic...

Trans-catheter aortic valve implantation is rapidly becoming an established modality of treatment for patients with critical aortic stenosis who are high risk for conventional aortic valve replacement. This approach also has its limitations; however, with growing experience and improvements in the delivery system, it may be possible to overcome these limitations. We describe a case where conven...

The Trans-Pacific Partnership Agreement (TPPA) involves twelve Pacific Rim economies of varying sizes and structures. Although often portrayed as a free trade agreement, the TPPA can, at best, be expected to deliver paltry overall growth gains from trade liberalization. The much higher figures touted by TPPA advocates are largely due to dubious ‘non-trade measures’, most of which have been reje...