Total parenteral nutrition (TPN), with the absence of enteral nutrition, results in profound changes to both intestinal epithelial cells (EC) as well as the adjacent intraepithelial lymphocyte (IEL) population. Intestinal EC are a rich source of IL-7, a critical factor to support the maintenance of several lymphoid tissues, and TPN results in marked EC changes. On this basis, we hypothesized th...

We examined interactions in a soluble tapasin (TPN)/HLA-B*0801 complex to gain mechanistic insights into the functions of TPN. Results show that TPN acts as a chaperone by increasing the ratio of active-to-inactive peptide-deficient HLA-B*0801 molecules in solution. TPN causes peptides to associate and dissociate faster owing to its effect on widening the binding groove of HLA-B*0801 molecules....

This paper presents a formal approach based on Time Petri net (TPN) for the coherence control of SMIL documents. TPN model has been widely used to specify real time systems. The question addressed by this paper is whether SMIL documents can be easily modelled by TPN model. For this purpose, we show how to translate a specification of a given document SMIL into a TPN. We have extended the TPN mo...

Penelitian mencoba untuk menentukan konsentrasi ekstrak akar tuba yang efektif meracuni patin (Pangasius pangasius) dan hubungan antara waktu pingsan pulih berdasarkan racun tuba. Indikatornya didasarkan atas tercepat terlama. Sebanyak 72 berukuran panjang total 13-37,5 cm dijadikan sebagai sampel penelitian. Konsentrasi minimal ditentukan 10 ppm, menengah 45 maksimal 80 ppm. < ppm tidak mem...

The most important challenge in the region-based abstraction method as an approach to compute the state space of time Petri Nets (TPNs) for model checking is that the method results in a huge number of regions, causing a state explosion problem. Thus, region-based abstraction methods are not appropriate for use in developing practical tools. To address this limitation, this paper applies a modi...

Total parenteral nutrition (TPN) results in a number of derangements to the intestinal epithelium, including a loss of epithelial barrier function (EBF). As TPN supplemented with glutamine has been thought to prevent this loss, this article further defined the impact of glutamine on EBF, and investigated potential mechanisms that contributed to the preservation of EBF. C57BL/6J male mice were r...

Total parenteral nutrition (TPN) has a vital role in controlling nutritional deficiencies especially in patients with critical conditions who are confined to bed in Intensive Care Unit (ICU). Complete evaluation of the nutritional status of these patients is necessary to achieve their nutritional goal. The aim of this investigation was to study the Complete Blood Count (CBC), coagulation parame...

BACKGROUND Routine total parenteral nutrition (TPN) in neonatal care can result in hepatic dysfunction in 40-60% of patients, most commonly as fatty liver, but little work has been conducted on the underlying mechanisms causing hepatic dysfunction. OBJECTIVE To use a piglet model for the premature human neonate on TPN, supplemented with lipid emulsions, to investigate hepatic responses. MET...

Nutrition support for patients in hospital has become an essential form of therapy. Total parenteral nutrition (TPN) was the preferred way of giving nutrition to hospital patients for many years but enteral nutrition (EN) is now the preferred route. EN is believed to promote gut function and prevent translocation of intestinal bacteria, thus reducing the incidence of sepsis in critically ill pa...

The ER protein tapasin (Tpn) forms a bridge between MHC class I H chain (HC)/beta(2)-microglobulin and the TAP peptide transporter. The function of this TAP-associated complex was unclear because it was reported that soluble Tpn that has lost TAP interaction would be fully competent in terms of peptide loading and Ag presentation. We found, however, that only wild-type human Tpn (hTpn), but not...