Correspondence to: Dr R Jalan, Liver Failure Group, Institute of Hepatology, University College London Medical School and University College London Hospitals, 69-75 Chenies Mews, London WC1E 6HX, UK; [email protected] _________________________ T his present review is timely with the increasing use of the molecular adsorbents recirculating system (MARS) for the management of liver failure, with ...

BACKGROUND Using a rat model of renal failure with normal parathyroid hormone levels, we had demonstrated previously that bone formation decreased depending on the degree of renal dysfunction, and hypothesized that uraemic toxins (UTx) are associated with the development of low-turnover bone development, complicating renal failure. In this study, focusing on indoxyl sulphate (IS) as a represent...

Background: This study intended to assess individual and combined adsorption potentials of three adsorbents (processed bentonite as an inorganic adsorbent, and cell walls of Saccharomyces cerevisiae and of the GG strain of Lactobacillus rhamnosus as organic adsorbents) for aflatoxin B1 and ochratoxin A under in vitro conditions. Methods: This study was conducted in Ferdowsi University of Mashh...

Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists. Despite advances in treatment of both cardiovascular and kidney disease, cardiorenal syndrome remains a major global health problem. Characteristic of the pathophysiology of cardiorenal syndrome is bidirectional cross-talk; mediators/substances activated by the dise...

In addition to causing uremic symptoms, uremic toxins accelerate the progression of renal failure. To elucidate the pathophysiology of uremic states, we investigated the effect of indoxyl sulfate (IS), a representative uremic toxin, on oxygen metabolism in tubular cells. We demonstrated an increase in oxygen consumption by IS in freshly isolated rat and human proximal tubules. Studies utilizing...

In this research, recipes were developed for beverages and desserts based on ”Vitalgar Cardio”, abiogelthat contains alginate, has therapeutic prophylactic properties, was produced from laminaria at the SPC ”Vita-Li” LLC. in its liquid form, as well it, is a source of soluble dietary fiber (alginates) chemical elements such potassium, magnesium iodine, an adsorbent various toxins, including rad...

<p>Dinitrobutylphenol is a toxic and resistant pollutant that pollutes the environment by producing toxins chemical wastewater. Present paper aims to study efficiency of magnetic particles walnut hard shell ash as cheap bi-compatible adsorbent for removable DNBP from aqueous environments. This was conducted at laboratory scale studied most important parameters including contact time, pH, ...

Toxins in water, such as metal ions and dyes, have become a global challenge to humanity by causing several serious illnesses. Removal of these toxins from water is needed for human health environmental concerns. This work investigated the use hemp seeds an environmentally friendly adsorbent applications treatment. Pristine (PHSs) were carbonized at 500 700 °C obtain carbon-based (CHS-500 CHS-7...

Here we describe a simple affinity purification method for Shiga toxin 2e (Stx2e), a major causative factor of edema disease in swine. Escherichia coli strain MV1184 transformed with the expression plasmid pBSK-Stx2e produced Stx2e when cultivated in CAYE broth containing lincomycin. Stx2e bound to commercial D-galactose gel, containing α-D-galactose immobilized on agarose resin via a divinyl s...

The use of monoclonal antibodies (MAbs) in cytotoxic conjugates (radionuclides, toxins, or drugs) for targeting tumor cells is restricted due to toxicity in vital organs. Through improved tumor targeting, it is possible to administer larger amounts of such labeled MAbs, thus improving the ability to eradicate tumor cells without increased normal organ toxicity. Extracorporeal affinity adsorptio...