Silver (Ag) nanomaterials (NMs) are used in many products, reaching the environment at some life stage. Their impact assessed via toxicokinetics differed between Ag salt and nano forms also with soil aging.

An Extensive Literature Search (ELS) by using PubMed, Web of Science and SciFinder for relevant studies on N-nitroso compounds (NOCs) analysed in food was performed. queries allowed to obtain a total number 18592 non-redundant references. The relevance analysis these references performed screening title abstract related the chemical identity characterisation, sources occurrence food, toxicokine...

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Most of the available data on chemical interactions have been obtained in animal studies conducted by administering high doses of chemicals by routes and scenarios different from anticipated human exposures. A mechanistic approach potentially useful for conducting dose, scenario, species, and route extrapolations of toxic interactions is physiological modeling. This approach involves the develo...

in toxicokinetics; AK UF , uncertainty factor for human variability in toxicokinetics; HPLC, high-performance liquid chromatograph. ABSTRACT Diuron, a widely used herbicide and antifouling biocide, has been shown to persist in the environment and contaminate the drinking water. It has been characterized as a " known/likely " human carcinogen. While the environmental transformation and toxicity ...

Acrylamide (AA) is a known mutagen and animal carcinogen. Comparison of recent studies revealed significant quantitative differences in AA-induced germ cell mutagenicity. It was hypothesized that despite the administration of AA at similar doses, the discrepancy in the observed effects was most likely due to varying AA concentrations in the administered dosing solution. To test this hypothesis,...

BACKGROUND Evaluation of interindividual variability is a challenging step in risk assessment. For most environmental pollutants, including perchloroethylene (PERC), experimental data are lacking, resulting in default assumptions being used to account for variability in toxicokinetics and toxicodynamics. OBJECTIVE We quantitatively examined the relationship between PERC toxicokinetics and tox...