Pyrrolizidine alkaloids (PA) are toxic for human and livestock. They undergo a metabolic toxication process in the liver which is the first target organ for PA poisoning. Worldwide many episodes of human PA intoxications are well reported. In many cases the reason for these intoxications has been PA contamination in food. The main tools for analysing food and fodder on PA content are based on G...

The Laboratory of Pharmacology initiates and carries out research programs that are primarily concerned with (1) mechanisms by which environmental pollutants and effectors cause toxicity, (2) the development of better test systems for detecting and evaluating early toxic effects of chemicals occurring as environmental contaminants, and (3) extrapolating from animal test systems across species a...

Cionura erecta (L.) Griseb., belongs to the Apocynaceae family, is one of poison plants in Turkey, widely grown Mediterranean region, and known as Babrik Turkey. In south east Anatolia, vernacular name plant Halava Kulf. Mello village Haliliye, district Şanlıurfa, poisoning sheep has been reported. This poisoned 120 herd 300 Haliliye Şanlıurfa. 50 seriously ill sheep,coordination disorder-weakn...

 Background: Methanol is a colorless and poisonous liquid that is commonly used as an industrial and household solvent. Methanol poisoning is a rare but extremely hazardous form of in toxication that affects the central nervous system and causes visual disorder, drowsiness, seizures and coma.  Case Presentation: A 29-years-old man with methanol intoxication presented with drowsiness and ac...

Hedyotis capitellata has widely used in traditional medicine for treatment of toxication, inflammation, diuretic, stomachache. H. capitellata has been showed to have antioxidant, anti-inflammatory and antibacterial effects. In this study we presented the acute and chronic anti-inflammatory and anticancer activities on HeLa, MCF7 and N87 cells line of H. capitellata. Our data showed that H. capi...

The role of intracellular Ca2+ in CCl4 hepatotoxicity in rats was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. Serum ALT activity clearly increased up to a peak value at 1 day after i.p. administration of CCl4 at 0.2 ml/kg, and then decreased to the control level after 3 days. Intracellular Ca2+ responded to CCl4 intoxication with...