Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, acute conditions, potentially life-threatening, immune-mediated often unpredictable.
 Characteristic for SJS TEN is necrosis of the epidermis mucous membranes, caused by extensive death keratinocytes. These syndromes considered hypersensitivity reactions. They most drugs. There have also been reports / being infe...

Toxic epidermal necrosis (TEN) is a life-threatening condition induced by a large variety of drugs, most often anticonvulsants, nonsteroidal anti-inflammatory drugs (NSAIDs) and sulphonamides; reports involving other drugs are available. We report the first case in which diacerein, an anthraquinone derivative recently introduced for rheumatological diseases, has been considered as a possible cu...

Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are among the most severe dermatologic reactions to the drugs. Data about SJS and TEN among pediatric population especially in Iran is limited. This study aimed to investigate the clinical and para-clinical characteristics of pediatric patients with SJS/TEN. Materials and Methods From 2010 to 2016, all SJS and TEN c...

Toxic epidermal necrolysis (TEN) is severe cutaneous hypersensitivity reaction characterized by necrosis of the epidermis and detachment of the epidermis and dermis that usually occurs as an idiosyncratic reaction to certain drugs. We report the case of a patient admitted to our Intensive Care Unit after an above-the-knee amputation who developed toxic epidermal necrolysis, possibly resulting f...

A case is described of a 59-year-old woman, who after oral intake of cefaclor presented with toxic epidermal necrolysis (TEN). Toxic epidermal necrolysis is characterized by widespread erythematous and bullous lesions on the skin caused by keratinocyte necrosis leading to exfoliation of epidermis, formation of erosions on mucous membranes and reactions from other organs. In the case of TEN diag...

OBJECTIVE To describe the ocular manifestations of Stevens-Johnson Syndrome/Toxic Epidermal Necrosis among inpatients at a tertiary care hospital. METHODS The retrospective observational descriptive study was carried out at the Aga Khan University Hospital, Karachi, and comprised data on age, gender, aetiology and ocular findings related to patients diagnosed with Stevens-Johnson Syndrome/Tox...

Toxic Epidermal Necrolysis (TEN) is an uncommon, idiosyncratic, potentially fatal dermatologic emergency affecting skin and mucous membranes. It characterized clinically by blistering widespread exfoliation, pathologically apoptosis of keratinocytes epidermal necrosis. Drugs are one the most common causative agents. The management ranges from nutritional support, care denuded mucosa to intraven...