Objective(s):  Apoptosis is a tightly regulated process and plays a crucial role in autoimmune diseases. Because abnormalities in apoptosis are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), in present study we studied the apoptosis in T lymphocytes from Iranian SLE patientsat protein and gene expression levels for some molecules which are involved in apopt...

colleagues [1] in a recent issue of Arthritis Research & Th erapy. Th ey hypothesized that co-transduction of CD4 + T cells with both forkhead box P3 transcription factor (FoxP3) and Bcl-xL will gener ate highly reactive regulatory T cells (Tregs) that can be used to prevent auto immune disease. Th e authors showed that the accu mulation, persistence, and effi cient function of Tregs were attri...

We report the case of a 54-year-old woman with progressive systemic sclerosis who presented erythematous papules diagnosed in biopsy as lichen planus bullous (LPB). Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by specific antibodies, vascular abnormalities with progressive damage of blood vessels and diffuse fibrosis leading to their failure. Sys-temic scler...

with no doubts regarding its benefi cial immunoprotective eff ect [1,2]. Recent reports have shown that adverse events are few and generally not life-threatening [3]. Th ere fore, a worldwide vaccination program was launched with very strong confi dence [4]. Herein, for the accumu-lative record, I report a possible life-threatening reaction of the monovalent H1N1 vaccine in Th ailand. A 38-year...

Objective(s):Genetic and environmental factors are involved in the pathogenesis of systemic lupus erythematosus (SLE). Autoreactive lymphocytes are cleared through apoptosis and any disturbance in the apoptosis or clearance of apoptotic cells may disturb tolerance and lead to autoimmunity. Vitamin D has anti-proliferative effects and controls cell cycle progression. In this study we investigate...

the most seasoned and savvy clinician views lupus warily, considering it one of the most bewildering diseases in all of medicine. Th is situation should not be a surprise since the manifestations of lupus are dizzying in their variety and exasperating in their subtlety. Furthermore , although lupus has been at the heart of immuno-logy research for decades, investigators have yet to fi gure out ...

A 9-year-old boy was referred to our pediatric department with symptoms of chronic fatigue, headache, intermittent nausea, and vomiting for 2 months. At admission a weight loss of 2 kg and intermittent subfebril temperature as well as an unspecific tremor of both hands was reported. He had a medical history of erythema migrans 2 years ago treated adequately with amoxicillin for 2 weeks. There w...

T of parts of the MHC has grown substantially within the last year. HE MAJOR HISTOCOMPATIBILITY complex (MHC) is an extended cluster of genes that are remarkable for the number and importance of the immunological functions The MHC is of major biomedical interest because of its contribution to transplant rejection and to variation between they encode. Historically, interest in the MHC emanated f...