Introduction: Autophagy is catabolic process involved in continuous removal of toxic protein aggregates and cellular organelles to maintain the homeostasis and functional integrity of cells. The mechanistic understanding of autophagy-mediated neuroprotection during aging remains exclusive. Here, we investigated the potential role of rapamycin-induced activation of autophagy and mTOR/Akt/CREB pa...

Fructose 2,6-bisphosphate (1) is formed by phosphorylation of fructose-6-phosphate, a key substrate in the glycolysis pathway, in a reaction catalyzed by phosphofructokinase-2 (PFK-2) [1]. Fructose-2,6-bisphosphate is a powerful allosteric regulator of glycolysis via its potent stimulatory effect on phosphofructokinase-1 activity and its in­ hibitory effect on fructose-1,6-bisphosphatase. The r...

In a continuation of studies on glycolytic and respiratory interrelationships in a series of rat hepatomas ranging widely in growth rate and degree of differentiation, whole, fortified homogenates of these tissues were incubated at 28°Cin the presence of frue tose-1,6-diphosphate (FDP), 2-deoxyglucose (2-DG), and exogenous hexokinase; respiration, lactate forma tion, and uptake of 2-DG were me...

In a continuation of studies on glycolytic and respiratory interrelationships in a series of rat hepatomas ranging widely in growth rate and degree of differentiation, whole, fortified homogenates of these tissues were incubated at 28°Cin the presence of frue tose-1,6-diphosphate (FDP), 2-deoxyglucose (2-DG), and exogenous hexokinase; respiration, lactate forma tion, and uptake of 2-DG were me...

OBJECTIVE The goal of this study was to evaluate the effect of protein energy malnutrition on protein glycosylation by investigating transferrin isoform pattern and its relationship to the degree of malnutrition and the biochemical markers of nutritional status in children. METHODS Forty one children with mild (n=23) and severely/moderately (n=18) acute malnutrition and 29 controls were enrol...

Glucose may be metabolized through the Embden-Myerhof glycolytic sequence to the threecarbon compounds, pyruvate and lactate. Alternatively, some of the glucose may be converted (a) to pentose via the hexose monophosphate shunt (1~) or (b) to serine and glycine by a series of reactions which probably branch from glycolysis at the level of phosphoglyceric acid (1, ~, 7, 8). The pyruvate and lact...

Glucose may be metabolized through the Embden-Myerhof glycolytic sequence to the threecarbon compounds, pyruvate and lactate. Alternatively, some of the glucose may be converted (a) to pentose via the hexose monophosphate shunt (1~) or (b) to serine and glycine by a series of reactions which probably branch from glycolysis at the level of phosphoglyceric acid (1, ~, 7, 8). The pyruvate and lact...

H. A k b a r i b, X. A l tuna b, S. Ba rd in b'l , R. Bel lazzini f, V. B i r y u k o v b'2, A. Brez f, M.P . Bussa h, L. Busso h, A. C a l c a t e r r a d, G. C a r b o n i f, F. C o s t a n t i n i f, R. D e Sangro d, K. E lsener b, F. Fer io l i b, A. Fe r r a r i b, G .P . Fer r i b, F. Fe r ron i g, G. F i d e c a r o b, A. F r e u n d c, R. G u i n a n d b, M. G y r b, W. H e r r b, A. Hi...