BACKGROUND AND OBJECTIVE In 1972, Dumas and Scholtz developed the psoriasis plaque test to evaluate the potency of local corticosteroids. Through further modification of this method, the efficacy between antipsoriatic products can be differentiated. This method allowed for the simultaneous application of several products to different test sites in the same psoriasis patient. The objective of th...

Scalp lesions are common in psoriasis and difficult to treat. Scientific evidence on the topic is scant and fragmentary, especially with respect to long-term treatment. This consensus statement is based on a critical assessment of the results of a MEDLINE search for clinical trials of the efficacy and safety of therapies used to treat scalp psoriasis. The recommendations were developed by an ex...

Background: Vitiligo is a relatively common acquired depigmentary disorder affecting approximately 1% of general population. PUVA therapy is the most effective modality and commonly used as the primary treatment of generalized Vitiligo. Objective: To evaluate the synergistic effect of topical Calcipotriol and oral methoxalene plus PUVA in treatment of generalized Vitiligo. Patients and Me...

BACKGROUND Topical therapies are the first line of treatment for patients with stable plaque psoriasis affecting a limited body surface area. Though in use for more than a decade, we could not find any reports of studies directly comparing calcipotriol and tazarotene. AIM To evaluate the comparative efficacy and tolerability of calcipotriol and tazarotene in the treatment of stable plaque pso...

In this paper, two methods are presented. One involves the separation of calcipotriol, a new synthetic analogue, from two related compounds, specifically cholecalciferol (Vitamin D3) and calcitriol (1,25-dihydroxyvitamin D3). The other involves the isolation and assay of calcipotriol from a topical ointment. The study was performed with reversed-phase high-performance liquid chromatography usin...

Background: Treatment of vitiligo remains an attractive topic and several therapies with varying degrees of success have been used. The aim of this study was to find out whether the combination of topical calcipotriol and excimer laser increases the efficacy of therapy compared to excimer laser alone. Methods: Twenty eight patients in two groups were treated with 308nm excimer laser alone (14 p...

The cutaneous sequelae of burns are usually temporary loss of pigment, hypertrophic scar and keloid. Infrequently skin neoplasia such as squamous cell carcinoma, basal cell carcinoma, malignant melanoma and sarcoma develop within the burn scar. Because ILVEN was developed after a burn in our patient, it is suggested that the possible mechanism for the development of ILVEN may have been that the...

porokeratosis with calcipotriol Editor, Disseminated superficial actinic porokeratosis (DSAP) is the most common type of porokeratosis. It is related to sun exposure and an autosomal dominant inheritance pattern is recognized. No ideal treatment of this clonal disorder of keratinization exists. We describe a patient in whom the complete resolution of lesions was achieved with topical treatment ...