The authors report interim clinical results from an ongoing NIH-sponsored trial to evaluate digital chest tomosynthesis for improving detectability of small lung nodules. Twenty-one patients undergoing computed tomography (CT) to follow up lung nodules were consented and enrolled to receive an additional digital PA chest radiograph and digital tomosynthesis exam. Tomosynthesis was performed wit...

Aims: The purpose of this review includes the following: 1) to identify indications for volumetric X-ray digital linear tomosynthesis by using a filtered back projection (FBP) algorithm and 2) to compare X-ray digital linear tomosynthesis, X-ray digital radiography, conventional tomography, and computed tomography. Review: The methods include the following: 1) an overview of the tomosynthesis s...

PURPOSE To determine the effect of implementing a screening tomosynthesis program on real-world clinical performance by quantifying differences between interpretation times for conventional screening mammography and combined tomosynthesis and mammography for multiple participating radiologists with a wide range of experience in a large academic center. MATERIALS AND METHODS In this HIPAA-comp...

Two-dimensional mammography is the major imaging modality in breast cancer detection. A disadvantage of mammography is the projective nature of this imaging technique. Tomosynthesis is an attractive modality with the potential to combine the high contrast and high resolution of digital mammography with the advantages of 3D imaging. In order to facilitate diagnostics and treatment in the current...

PURPOSE To assess cancer detection rates, false-positive rates before arbitration, positive predictive values for women recalled after arbitration, and the type of cancers detected with use of digital mammography alone and combined with tomosynthesis in a large prospective screening trial. MATERIALS AND METHODS A prospective, reader- and modality-balanced screening study of participants under...

The present study was performed to determine the potential of applying dual-energy subtraction (DES) digital tomosynthesis to basic physical evaluations. Volumetric X-ray DES digital tomosysnthesis was used to obtain an image of a detectability phantom (an artificial lesion). The image quality of DES digital tomosynthesis was compared to that of DES radiography. The purpose of this study was to...

OBJECTIVE To estimate and compare the diagnostic validity of tomosynthesis and digital mammography for screening and diagnosing breast cancer. MATERIAL AND METHODS We systematically searched MedLine, EMBASE, and Web of Science for the terms breast cancer, screening, tomosynthesis, mammography, sensitivity, and specificity in publications in the period comprising June 2010 through February 201...

AIM The clinical utility of digital linear tomosynthesis in musculoskeletal applications has been validated in only a few reports. Technical performance and utility in hip prosthesis imaging have been discussed in technical reports, but no clinical evaluation has been reported. The purpose of the current study was to assess the added clinical utility of digital linear tomosynthesis compared to ...

We demonstrated a depth-resolved 3D imaging technique based on absorption contrast using tomosynthesis. Tomosynthesis is similar to computed tomography except that the number of projections is much smaller. We constructed a tomosynthesis imaging system, which detects a transmitted continuous THz wave. We applied a backprojection method that was suitable for the constructed detection configurati...

Digital breast tomosynthesis is rapidly being implemented in breast imaging clinics across the world as early clinical data demonstrate that this innovative technology may address some of the long-standing limitations of conventional mammography. This article reviews the recent clinical data supporting digital breast tomosynthesis implementation, the basics of digital breast tomosynthesis image...