1. Toltrazuril, a triazinetrione derivative, is intended for use in chickens and turkeys for the prevention and treatment of coccidiosis. Administration is via drinking water at 25 mg/l for continuous administration over 48 hours or at 75 mg/l given for 8 hours per day, on 2 consecutive days. Both treatments correspond to a dose of approximately 7 mg toltrazuril/kg bw/day. For curative treatmen...

This trial was undertaken with the objective to evaluate the efficacy of amprolium, toltrazuril and their combination in rabbits naturally infected with Eimeria species (32 × 103 ± 4.63 oocysts per gram (OPG) of faeces). Thirty-six rabbits (11 weeks old with average body weight (BW) 2000 ± 75 g), were randomly allocated into six groups (six kits each), namely, negative untreated and was retaine...

Coccidiosis is an enteric disease caused by protozoa, especially Cystoisospora suis which can lead to large losses in production. Its transmission occurs through different routes, mainly affecting piglets the first weeks of life and normally progressing with diarrhea unresponsive antibiotic therapy. The objective this work was evaluate, two seasons year, occurrence C. sows, routes source infect...

BACKGROUND Piglet isosporosis is one of the most common parasitic diseases in modern pig production. To prevent clinical disease, prophylactic treatment of piglets with toltrazuril (BAYCOX® 5%, Bayer HealthCare, Animal Health, Monheim, Germany) is widely practiced in the past 20 years. There are only very few reports documenting the likely effect of managerial practices, such as hygiene measure...

The histophagous ciliate Philasterides dicentrarchi causes fatal scuticociliatosis in farmed turbot Scophthalmus maximus and sea bass Dicentrarchus labrax. The present study screened 52 candidate antiprotozoals for activity against this pathogen in vitro. Of these compounds, 14 were effective (i.e. killed all ciliates within a 24 h assay period). In descending order of efficacy (minimum lethal ...

The activity of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase, total protein, albumin and cholesterol levels were determined in the blood serum of Japanese quails infected with coccidia and treated with Baycox (active ingredient: toltrazuril). Lower levels of AST and ALT activity were noted in treated birds regardless of the applied Baycox dose. The biochemical ...

Kudoa septempunctata (Myxozoa: Multivalvulida) myxospores infect the trunk muscles of olive flounder (Paralichthys olivaceus). In this study, two popular commercially formulated anti-coccidial drugs (amprolium hydrochloride and toltrazuril) were serially diluted and incubated with purified mature Kudoa septempunctata myxospores. The viability of K. septempunctata spores was determined after a 2...

This study aimed to evaluate and compare the efficacy of treatment with a single dose toltrazuril 5% (Baycox), thymol (Versatile, Nine Life, United Arab Emirates), + combination control Eimeria spp. infection in lambs intensive feeding. The was designed five groups these aligned as; group 1 (negative group; NEG), 2 (positive POZ), 3 (thymol; THY), 4 (toltrazuril; TOL) 5 [(thymol toltrazuril; (T...

Eimeria türlerinin neden olduğu koksidiyoziste kuzu ve oğlaklarda diyareye olan etkenlerden biridir. Kuzu oğlaklarında akut koksidiyozis tedavisinde toltrazuril’in oldukça etkili bilinse de canlıda nasıl etkiler oluşturduğu ile ilgili bilgiler sınırlıdır. Bu nedenle bu çalışmada Honamlı ırkı oğlakların doğal koksidiyozisinin toltrazuril uygulamasının hayvanda etkiler, serum oksidatif stres düze...