OBJECTIVE To evaluate the protective value of quercetin, gossypin, Hippophae rhamnoides (HR) flavone and tocopherol acetate against the systemic toxicity of percutaneously administered sulphur mustard (SM) in mice. MATERIALS AND METHODS Quercetin, gossypin, HR flavone or tocopherol acetate (200 mg/kg, i.p.) were administered just before percutaneous administration of SM and protection against...

The biological function of the stereoisomers of a-tocopherol is believed to depend on their bioavailability. Assessment of bioavailability within the body is therefore considered to be a good and easy way to predict biological value. The separation of a-tocopherol methyl ethers by chiral column HPLC is a good and easy tool with which to study the distribution of a-tocopherol stereoisomers. The ...

The lack of biochemical data to indicate the prevalence of marginal vitamin A deficiency (VAD) in the country is largely because of the difficulty of obtaining enough serum for analysis, especially from malnourished children. Efforts were therefore made to establish a high-pressure liquid chromatography system (HPLC) for the determination of retinol in micro-volumes of serum. Since our previous...

It is well-established that amount of deoxyribonucleic acid (DNA) per somatic cell for a given species remains constant, irrespective of the nutritional status of the animal (1). Therefore, any variation in the mean amount of DNA per organ must be attributed to variations in either the mass or the number of cells of the tissue concerned. In the course of an investigation into the ac tivity of c...

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Extravasation of Adriamycin during i.v. infusion can cause serious local complications. We have used a rat skin model to study the protection afforded by dimethyl sulfoxide and alpha-tocopherol (vitamin E) against Adriamycin-induced skin necrosis. Topical daily application of 1 ml dimethyl sulfoxide for 2 days produced a small decrease in ulcer diameter of up to 11% at 2 weeks. Topical daily ap...

Aged humans and animals demonstrate cognitive decline. Improvement of short-term memory performance in aged beagles with a nutraceutical supplement containing phosphatidylserine (PS) and vitamin E has been demonstrated. The purpose of the present study was to examine if alpha-tocopherol acetate could alter PS metabolism in the hippocampus and to improve cognitive function of aged rats. Intragas...

Abstract Background Direct measurement of the bioavailable α-tocopherol content presents a significant analytical challenge and requires chiral separation stereoisomers. Objective The objective study was to validate an method for analysis stereoisomers in infant formulas dairy products. Method Samples were saponified at elevated temperature lipophilic components extracted into organic solvent, ...

Effects of α-, β-, γ- and δ-tocopherols on the proliferation and invasion of AH109A hepatoma cells and their modes of action were investigated. Four tocopherols inhibited the invasion as well as the proliferation of AH109A cells. Their inhibitory effects were more prominent on the invasion than on the proliferation. At 1 µM, α-tocopherol showed most potent anti-invasive activity without any inf...

Myxinol tetra-acetate was examined by both nuclear-magnetic-resonance and mass-spectral techniques. The results are compared with corresponding data for 5alpha-ranol tetra-acetate and 5alpha-cyprinol tetra-acetate. The structure deduced for myxinol tetra-acetate, 3beta,7alpha,16alpha,27-tetrahydroxy-5beta-cholestane, is in agreement with that simultaneously arrived at by Haslewood (1966).