Background: Toll-like receptors (TLRs) constitute a major part of innate immunity, which can distinguish pathogen associate molecular pattern. Sertoli cells create a special immunological niche that protects somniferous tubules from auto antigens and pathogens. These cells are the only somatic cells in somniferous that protect testis cells against pathogens. The purpose of this study was to eva...

Objective(s): TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation of AMPK could inhibit LPS-induced Tlr-4 gene expression in mice hearts. Materials and methods: Heart AMPK activity and/or Tlr-4 expression was stimulated in different mice groups, using respectively IP i...

conclusions to date, a large number of viruses are proved to trigger innate immunity via tlrs, suggesting that these receptors are likely to be important in the outcome of viral infection. this suggestion is supported by the observation that many viruses have evolved mechanisms not only to evade the innate immune system, but also to subvert it for the benefit of the virus. materials and methods...

objective(s): tlr-4 activates a number of inflammatory signaling pathways. also, ampk could be involved in anti-inflammatory signaling. the aim of this study was to identify whether stimulation of ampk could inhibit lps-induced tlr-4 gene expression in mice hearts. materials and methods: heart ampk activity and/or tlr-4 expression was stimulated in different mice groups, using respectively ip i...

a new, local agro-industrial waste was valorized by chemical treatment and tested for its ability to remove cationic dye from aqueous solution. tendu (diospyros melanoxylon) leaves refuse, a solid waste from bidi industry which caused disposal problem, was studied as a biosorbent. raw tendu waste (tlr), along with sulfuric acid carbonized tendu waste (tlr-cm) and tendu waste treated with dilute...

background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...

Background: Toll-like receptors (TLRs) detect diverse pathogen-associated molecular patterns and play a critical role in the innate immune response. Hosts should activate TLR-signaling pathways to eliminate invading pathogens. However, excessive activation of these pathways may interrupt immune homeostasis, leading to several diseases. Therefore precise regulation of TLR-signaling pathways is e...