A simple, sensitive and rapid spectrophotometric method was developed and validated for the determination of two skeletal muscle relaxants namely, tizanidine hydrochloride (I) and orphenadrine citrate (II) in pharmaceutical formulations. The proposed method is based on the formation of a binary complex between the studied drugs and eosin Y in aqueous buffered medium (pH 3.5). Under the optimum ...

BACKGROUND AND PURPOSE Spasticity is a frequently observed motor impairment that develops after stroke; it can cause pain and disability in those affected. The objective of the present study was to evaluate the safety and efficacy of tizanidine, a centrally acting alpha(2)-adrenergic agonist, in the treatment of stroke-related spasticity. METHODS Forty-seven patients, who were a minimum of 6 ...

A new simple, accurate and precise HPTLC method has been developed for the simultaneous estimation of tizanidine and rofecoxib in tablet formulation. In this method, standard and sample solutions of tizanidine and rofecoxib were applied on precoated silica gel G 60 F254 TLC plate, and developed using nbutyl acetate: formic acid: chloroform (6:4:2 v/v/v), as mobile phase. The drugs on plate were...

The efficiency and duration of action of a single oral dose (8 mg) of tizanidine in patients with spinal cord injuries were determined by studying its antispastic, cardiovascular and sedative effects along with its pharmacokinetic profile in five tetraplegic and five paraplegic patients. After the administration of tizanidine, there was a reduction in spasticity in both groups within half an ho...

BACKGROUND Direct laryngoscopy and tracheal intubation can result in blood pressure and heart rate increase which in turn may lead to myocardial ischemia, cerebral hemorrhage, and even death in susceptible patients. Tizanidine is α2-receptor agonists that suppresses central sympathetic system. OBJECTIVES This study evaluates the effects of oral Tizanidine on hemodynamic responses during opera...

objectives this study evaluates the effects of oral tizanidine on hemodynamic responses during operations and aims to determine the appropriate propofol dosage to maintain anesthesia under bis monitoring. materials and methods a double-blind clinical trial has been performed on 70 candidates for elective abdominal surgery undergoing general anesthesia in educational hospital of ghaem, mashhad, ...

Cystitis is a possible adverse drug reaction associated with the use of tizanidine. Such cases have been rarely reported in literature because of the difficulty in establishing the causality. However, from a pharmacovigilance point of view, it is better to report such cases of a possible association between a drug's use and potential adverse drug reactions. We report a case of a 26-year-old Asi...

Spasticity is a common disabling feature of multiple sderosis. A variety of drugs are in regular use as oral treatment induding badofen, dantrolene, tizanidine, and diazepam. Published evidence of effectiveness is limited. Most trials are of small size, of short duration, and have not reported on functional outcomes. Studies have been published which suggest that badofen, tizanidine, and diazep...

objective spastic cerebral palsy (cp) is one of the most difficult and disabling conditions that requires medical attention and treatment. the aim of this study was to assess the efficacy and safety of oral tizanidine in treating spasticity in children with spastic cp. materials & methods sixty children with spastic cerebral palsy were enrolled in a double-blind, placebo-controlled, randomized ...

A new process impurity was detected during the HPLC analysis of Tizanidine hydrochloride (I) batches. The impurity (II) was isolated by preparative HPLC and characterized by NMR and Mass spectral analysis as 5-S-ethyl-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride.