Three simple methods using visual titrimetric, potentiometric and spectrophotometric techniques are described for the determination of acyclovir in pure form and in pharmaceutical formulations. The methods are based on the neutralisation reaction involving the primary amino group of the drug and acetous perchloric acid in acetic acid medium. In titrimetric methods, the titration is completed wi...

The spectrophotometric method described is quick and effective and a reliable alternative to a titrimetric method for measuring trypsin activity in duodenal juice.

SINcE the publication of von Fellenberg's method [1923] for the determination of small quantities of iodine, a very large number of new methods and modifications have been described, some of which claim a surprising degree of accuracy. The multiplicity of methods is sufficient to show that none of them is really satisfactory. The von Fellenberg method includes two methods for the final determin...

When aggregated micelles of phospholipids are hydrolysed by phospholipase A2 (PLA2) in an aqueous dispersion, scattering from the solution is decreased. Hydrolysis of dimyristoyl phosphatidylcholine by PLA2 from Russell’s viper venom has been investigated using a spectrofluorimeter at 650 nm. The rate of decrease in scattering was linearly dependent with venom concentration, while the initial l...

This investigation was aimed at comparing a new method for measuring faecal fat excretion, carried out with a semi-automated instrument by using near infrared analysis (NIRA), with the traditional titrimetric (Van de Kamer) and gravimetric (Sobel) methods. Near infrared analysis faecal fat was assayed on the three day stool collection from 118 patients (68 chronic pancreatitis, 19 organic disea...

abstract: Ascorbic acid (Vitamin C) is an essential Vitamin which participates in many different biological processes. The ascorbic acid content in vegetables and fruits is a maturity index and its determination in such samples is of special interest in quality control. In this paper we present a titrimetric method with potassium bromide for the determination of ascorbic acid in walnut, cabbage...

HE PRESENT s’ru was suggested by the lack of data on plasma tnbutyrinase (lipase) activity in the neonatal period. Titrimetric methods are not practical for small amounts of blood and it was found necessary to adapt the method of Goldstein et al. (1) to an electrometric procedure. Such a modification reduced to %o the amount of plasma and reagents needed in the titrimetric method. Troescher and...

Two titrimetric and two spectrophotometric methods are described for the assay of famotidine (FMT) in tablets using N-bromosuccinimide (NBS). The first titrimetric method is direct in which FMT is titrated directly with NBS in HCl medium using methyl orange as indicator (method A). The remaining three methods are indirect in which the unreacted NBS is determined after the complete reaction betw...