Adhesion to wet and dynamic surfaces, including biological tissues, is important in many fields but has proven to be extremely challenging. Existing adhesives are cytotoxic, adhere weakly to tissues, or cannot be used in wet environments. We report a bioinspired design for adhesives consisting of two layers: an adhesive surface and a dissipative matrix. The former adheres to the substrate by el...

Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention particularly in minimally invasive procedures. For safe and accurate applications, tissue adhesives should be detectable via clinical imaging modalities ...

Background: Cyanoacrylate tissue adhesives have been used as a substitute to silk for intraoral wound closure. Placement of sutures provides a corridor for accumulation of microorganisms into tissue which leads to infection. Cyanoacrylate-based adhesives exhibit many properties of an ideal wound closure agent, minimizing the problems generated by suturing thread. The antimicrobial properties of...

REFERENCE/CITATION Farion K, Osmond MH, Hartling L, et al. Tissue adhesives for traumatic lacerations in children and adults. Cochrane Database Syst Rev. 2001(4);CD003326. CLINICAL QUESTION What is the clinical evidence base for tissue adhesives in the management of simple traumatic lacerations? DATA SOURCES Studies were identified by searches of the following databases: Cochrane Wounds Gro...

Tissue adhesives are attractive materials with potential to replace the use of sutures and staples in the repair of the injured tissues. The research field of tissue adhesives is dynamically growing, and different methods and tissue models are employed to evaluate the adhesive properties of newly developed materials. It is thus difficult to directly compare the properties of materials developed...

In the past two decades tissue adhesives and sealants have revolutionized bleeding control and wound healing. This paper focuses on existing tissue adhesive design, their structure, functioning mechanism, and their pros and cons in wound management. It also includes the latest advances in the development of new tissue adhesives as well as the emerging applications in regenerative medicine. We e...

The ideal method of wound closure in children who present to the accident and emergency department with lacerations, is painless, rapid, easy to perform, safe, and results in minimal scarring. Tissue adhesives have relatively recently been used as a “no needle” alternative to conventional suturing. This review reports on the development of tissue adhesives and analyses how close they are to thi...

Ocular tolerance to cyanoacrylate tissue adhesives was evaluated in rabbits. In the experimental studies, tissue adhesives were implanted intralamellarly, subconjunctivally, and in the anterior chamber. The eyes were examined clinically and histologically at different time intervals. In the cornea and conjunctiva, the adhesive reacted as any inert material. The reaction was considerably less th...