Recent evidence suggests that increased inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) formation is involved in the pathogenesis of endothelial dysfunction in heart failure (HF). However, it is unclear whether increased OFR limits coronary flow reserve in HF. To test this hypothesis, we examined the effects of antioxidant therapy on coronary flow reserve in a...

Recent evidence suggests the possibility that enhanced inactivation of endothelium-derived nitric oxide (NO) by oxygen free radical (OFR) may cause endothelial dysfunction in heart failure (HF). To test this hypothesis, we examined the effect of antioxidant therapy on endothelium-dependent vasodilation of the coronary circulation in a canine model of tachycardia-induced HF. Endothelium-dependen...

The equilibrium constants and kinetics for the complexing of aqueous iron(m) by 2,3dihydroxybenzoic acid (DHB) and 1,2-dihydroxy-3~-benzenedisulfo~te (Tiron) have been studied with iron(IIl) in excess over ligand. Formation constant comparisons indicate that DHB complexes in a mode analogous to salicylate. The reaction rate has the hydrogen ion dependence typical for iron(m) complexation, but t...

Present investigation was planned to evaluate the therapeutic effectiveness of chelating agents against vanadium intoxication on blood and reproductive organs of rats. Male and female albino rats were injected vanadyl sulphate (7.5 mg/kg, po, for 21 days, 5 days in a week). Chelating agents tiron (T) alone and in combination with lipoic acid (LA), vitamin E (vit E) and selenium (Se) were given ...

Reactive oxygen species (ROS) are metabolism by-products that may act as signaling molecules to sustain tumor growth. Antioxidants have been used to impair cancer cell survival. Our goal was to determine the mechanisms involved in the response to antioxidants of a human cell culture (PT4) containing glioblastoma (GBM) tumorigenic initiating cells (TICs). ROS production in the absence or presenc...

UO2 (II) – ferron complex solution in ethanol and also Fe (II) – ferron or tiron complexes, and Fe (III) – ferron or tiron complexes in aqueous solutions were prepared and their composition was determined by the molar ratio method. The complex solutions formed were found to obey Beer`s law within certain concentration ranges. The color bleaching of these complex solutions upon gamma irradiation...

The superoxide anion ([Formula: see text]) appears to be an important modulator of nitric oxide (NO ⋅) bioavailability. The present study was designed to characterize the role of copper/zinc superoxide dismutase (Cu/Zn SOD) in endothelium-dependent relaxations. Cu/Zn SOD was inhibited with the Cu2+chelator diethyldithiocarbamic acid (DETCA). In isolated canine basilar arteries, DETCA (7.6 × 10-...