.he incorporation of S-35-labeled sulfate by slices of conjunctiva and ventral lacrymal and Harderian glands of the guinea pig was studied in an in vitro system. Sulfation of these tissues, particularly of the Harderian gland, resembled an enzymatic reaction in its temperature and pH characteristics and its dependence upon the viability of the tissues. Thyrotrophic hormone (TSH) added to the in...

The accidental observation that the thyroid gland of the tumor-bearing rat was not enlarged after the oral administration of thiouracil was made while investigating the possible role of the thyrotrophic hormone (TSH) as a fat-mobilizing hormone (14). Further experiments were carried out to ensure that the effect was not limited to a particular strain of rat or type of tumor, or due to the actio...

It has been shown (Selye, 195 lb) that in unilaterally nephrectomized rats drinking 1 per cent. NaCi, electrophoretically homogeneous preparations of growth hormone (STH) caused nephrosclerosis, polyuria, myocarditis, and hypertension. This syndrome very closely resembles that produced by desoxycorticosterone acetate (DCA). However, one striking difference between the effects of STH and DCA is ...

1. This study has evaluated the effect of somatostatin (0.1 or 3 micrograms/ml) on the release of thyroxine, 3,5,3'-tri-iodothyronine and 3,3',5'-tri-iodothyronine from perfused thyroid lobes. 2. Somatostatin did not affect either the total relase of iodothyronines or the ratio between various iodothyronines in thyroid effluent from unstimulated and thyrotrophic hormone stimulated thyroid lobes...

By JAMES W. FIsm R, B. L. ROH, CHARLES COUCH AND W. 0. NIGHTINGALE E RYTHROPOIESIS is known to be stimulated by several hormonal substances. ACTH,12 adrenocortical steroids,34 thyrotrophic and thyroid hormones,1’5 growth hormone3 and testosterone are hormones that have been shown to stimulate erythropoiesis in either intact or hypophysectomized rats. Cobalt has been known for several decades to...

A 24-year-old woman was admitted with general weakness, umbilical swelling, developmental delay, speech disorder, constipation, gait problem. Her findings were umbilical hernia, xerosis, dry hair, and short stature. After thyroxine treatment, she also had headache, vomiting, and palpitation, lack of appetite, and sleep disturbance. Pituitary magnetic resonance imaging revealed a heterogeneous m...