background: the phosphatidylinositol 3-kinase/akt signaling pathway is recognized as a key driver of cancer cell survival and proliferation, and is often contingent upon an impairment of expression/function of the pten tumor suppressor, a negative regulator of this pathway. in addition, the cytoskeletal signaling protein tensin 2 has also been implicated as a negative regulator of this pathway....

introduction: a thyroid nodule is a palpable swelling in a thyroid gland with an otherwise normal appearance. palpable thyroid nodules occur in 4 to 7 percent of the population. nodular thyroid diseases are more frequent in women than in men. most actions of thyroid hormone are mediated by the active form of thyroid hormone. d2 is essential for formation of active hormone of t3 through deiodina...

background: radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 gy for non-myeloablative therapies. the aim of this study was to calculate bone marrow radiation dose by using mirdose3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. materials and methods: in t...

background: due to volatility of radioactive iodine solutions, usually internal exposure would occur in personnel that are working in nuclear medicine centers. the activities in the thyroid of individual s who work in nuclear medicine centers of north west provinces of iran were measured using nai (sodium iodide) detectors. in every center, nearly 40 - 500 mci of 131 i and 50 - 600 μ ci of 125 ...

Background: Radiation absorbed dose to the red bone marrow, a critical organ in the therapy of thyroid carcinoma, is generally kept below 2 Gy for non-myeloablative therapies. The aim of this study was to calculate bone marrow radiation dose by using MIRDOSE3 package program and to optimize the safe limit of activity to be administered to the thyroid cancer patients. Materials and Methods: In t...

Background: Due to volatility of radioactive iodine solutions, usually internal exposure would occur in personnel that are working in nuclear medicine centers. The activities in the thyroid of individual s who work in nuclear medicine centers of North West provinces of Iran were measured using NaI (Sodium Iodide) detectors. In every center, nearly 40 - 500 mCi of 131 I and 50 - 600 μ Ci of 125 ...

A 34 year old woman with malaise, polyuria and nocturia as well as nausea and vomiting referred to perform a thyroid scan due to right thyroid lobe mass. The scan showed a cold nodule in the right thyroid lobe. Serum calcium of 16.9, serum phosphorus of 1.8 and PTH of 1156 were noticed in laboratory tests. Parathyroid scan with 99mTc-MIBI showed no abnormal tracer activity in the nec...

The effects of some exogenous peripheral hormones (thyroxine, corticosterone, epinephrine, norepinephrine and insulin) on thyroid activity were investigated in juvenile female soft-shelled turtles, Lissemys punctata punctata. Each hormone was injected in three different doses (25 microg, 50 microg or 100 microg each per 100 g body weight, once daily at 9 AM) for 10 consecutive days. Thyroid act...